Diketopirerazine (DKP) is a chemical compound. It is the cyclic anhydride of the dipeptide glycylglycine. The compound was the first peptide to have its complete, three-dimensional structure figured out, in work undertaken at Caltech by Robert Corey in the 1930s. The compound's full name is 5-benzyl-3, 6-dioxo-2-piperazine acetic acid. In chemistry, an anhydride is typically an oxide of a nonmetallic element or an organic radical, capable of forming an acid by uniting with the elements of water. ... A dipeptide is a molecule consisting of two amino acids joined by a single peptide bond. ... Glycine is a nonpolar amino acid. ...

Diketopirerazine occurs as a by-product of aspartame metabolism, and it also occurs in liquid aspartame-containing products during prolonged storage, usually at temperatures above 30 degrees Celsius. The compound has been implicated in the occurrence of brain tumors and has also been implicated as a cause of uterine polyps and changes in blood cholesterol by FDA toxicologist Dr. Jacqueline Verret in her testimony before the U.S. Senate. Aspartame is the name for the artificial, non_carbohydrate sweetener, Aspartyl-phenylalanine-1-methyl ester; i. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος(metavallo), the Greek word for change), in the most general sense, is the ingestion and breakdown of complex compounds, coupled with the liberation of energy, and the consequent generation of waste... A brain tumor is any mass created by an abnormal and uncontrolled growth of cells either found in the brain (neurons, glial cells, epithelial cells, myelin producing cells, etc. ... Female internal reproductive anatomy The uterus or womb is the major female reproductive organ of most mammals, including humans. ... Polyp of sigmoid colon as revealed by colonoscopy. ... Cholesterol is a steroid lipid, found in the cell membranes of all body tissues, and transported in the blood plasma of all animals. ... The United States Food and Drug Administration (FDA) is the government agency responsible for regulating food (human and animal), dietary supplements, drugs (human and animal), cosmetics, medical devices (human and animal), biologics and blood products in the United States. ... Toxicology (from the Greek words toxicon and logos) is the study of the adverse effects of chemicals on living organisms. ... The United States Senate is the upper house of the U.S. Congress, smaller than the United States House of Representatives. ...