 | | Diltiazem | | Systematic (IUPAC) name | [2-(2-dimethylaminoethyl)-5-(4-methoxyphenyl)
-3-oxo-6-thia-2-azabicyclo[5.4.0]undeca-7,9,
11-trien-4-yl]ethanoate | | Identifiers | | CAS number | 42399-41-7 | | ATC code | C08DB01 | | PubChem | 39186 | | DrugBank | APRD00473 | | Chemical data | | Formula | C22H26N2O4S | | Mol. weight | 414.519 g/mol | | Pharmacokinetic data | | Bioavailability | 40% | | Metabolism | Hepatic | | Half life | 3-4.5 hours | | Excretion | Renal
Biliary
Lactic (in lactiferous females) | | Therapeutic considerations | | Pregnancy cat. | D: (USA) Image File history File links Diltiazem. ...
IUPAC nomenclature is a systematic way of naming organic chemical compounds. ...
CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ...
The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ...
A section of the Anatomical Therapeutic Chemical Classification System. ...
PubChem is a database of chemical molecules . ...
DrugBank is a database available at the University of Alberta that provides information about thousands of products. ...
A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ...
General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Atomic mass 12. ...
General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ...
General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless Atomic mass 14. ...
General Name, Symbol, Number oxygen, O, 8 Chemical series Nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Atomic mass 15. ...
General Name, Symbol, Number sulfur, S, 16 Chemical series nonmetals Group, Period, Block 16, 3, p Appearance lemon yellow Atomic mass 32. ...
The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ...
BIC pen cap, about 1 gram. ...
The mole (symbol: mol) is the SI base unit that measures an amount of substance. ...
In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ...
It has been suggested that this article or section be merged with cell metabolism and carbohydrates. ...
The liver is an organ in living beings, including humans. ...
The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ...
The hour (symbol: h) is a unit of time. ...
Excretion is the biological process by which an organism chemically separates waste products from its body. ...
Human kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ...
Bile (or gall) is a bitter, greenish-yellow alkaline fluid secreted by hepatocytes from the liver of most vertebrates. ...
Cross section of the breast of a human female. ...
The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...
| | Legal status | | | Routes | Oral | Diltiazem is a member of the group of drugs known as Benzothiapines , which are a class of calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It is a class 3 anti anginal drug. It incites very minimal reflex sympathetic changes. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ...
In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ...
Look up Mouth in Wiktionary, the free dictionary. ...
Diltiazem. ...
Calcium channel blockers are a class of drugs with effects on the muscle of the heart and the muscles of the rest of the body. ...
For other forms of hypertension see hypertension (disambiguation). ...
A cardiac arrhythmia, also called cardiac dysrhythmia, is a disturbance in the regular rhythm of the heartbeat. ...
Diltiazem is a potent vasodilator, increasing blood flow and variably decreasing the heart rate via strong depression of A-V node conduction. A vasodilator is a substance that causes blood vessels in the body to become wider by relaxing the smooth muscle in the vessel wall, or vasodilation. ...
Diltiazem is metabolized by and acts as an inhibitor of the CYP3A4 enzyme. Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1. ...
Diltiazem is contraindicated in the presence of Sick sinus syndrome, Atrioventricular node conduction disturbances, Bradycardia, impaired Left ventricle function, Peripheral artery occlusive disease, Chronic obstructive pulmonary disease, and Prinzmetal's angina. Sick sinus syndrome, also called Bradycardia-tachycardia syndrome is a group of abnormal heartbeats (arrhythmias) presumably caused by a malfunction of the sinus node, the hearts natural pacemaker. ...
The atrioventricular node (abbreviated AV node) is the tissue between the atria and the ventricles of the heart, which conducts the normal electrical impulse from the atria to the ventricles. ...
Bradycardia, as applied in adult medicine, is defined as a heart rate of under 60 beats per minute, though it is seldom symptomatic until the rate drops below 50 beat/min [1]. It is also less commonly known as brachycardia. ...
In the heart, a ventricle is a chamber which collects blood from an atrium (another heart chamber) and pumps it out of the heart. ...
In medicine (vascular surgery), Peripheral artery occlusive disease (PAOD) (also known as Peripheral vascular disease or PVD) is a collator for all disease caused by the obstruction of large peripheral arteries, which can result from atherosclerosis, inflammatory processes leading to stenosis, an embolism or thrombus formation. ...
Chronic obstructive pulmonary disease (COPD) is an umbrella term for a group of respiratory tract diseases that are characterized by airflow obstruction or limitation. ...
Prinzmetals angina, also known as variant angina or angina inversa, is a syndrome typically consisting of angina (cardiac chest pain) at rest that occurs in cycles. ...
Brand names - Cardizem®
- Cartia XT®
- Tiazac®
- Tiamate®
- Adizem®
| Calcium channel blockers (C08) edit | | Dihydropyridines: | Amlodipine, Felodipine, Isradipine, Lacidipine, Lercanidipine, Nicardipine, Nifedipine, Nimodipine, Nisoldipine Calcium channel blockers are a class of drugs with effects on the muscle of the heart and the muscles of the rest of the body. ...
A section of the Anatomical Therapeutic Chemical Classification System. ...
Pyridinium cation of pyridine. ...
Amlodipine (as besylate or malleate) is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. ...
Felodipine is a calcium channel blocker (calcium antagonist), a drug used to control hypertension (high blood pressure). ...
Isradipine is a calcium channel blocker of the dihydropyridine class. ...
Lercanidipine is a calcium channel blocker of the dihydropyridine class. ...
Nicardipine hydrochloride (Cardene®) is a medication used to treat high blood pressure and angina. ...
Nifedipine (brand name Adalat and Procardia) is a dihydropyridine calcium channel blocker. ...
Nimodipine (marketed by Bayer as Nimotop®) is a dihydropyridine calcium channel blocker originally developed for the treatment of high blood pressure. ...
Nisoldipine is a calcium channel blocker of the dihydropyridine class. ...
| | Phenylalkylamines: | Verapamil Verapamil (brand names: Isoptin®, Verelan®, Calan®) is a medical drug that acts as an L-type calcium channel blocker. ...
| | Benzothiazepines: | Diltiazem Diltiazem. ...
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