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Terpenes Arrest Parasite Development and Inhibit Biosynthesis of Isoprenoids in Plasmodium falciparum -- Rodrigues ... (4480 words) |
 | All the terpenes inhibited dolichol biosynthesis in the trophozoite |
| inhibited biosynthesis of dolichol in the trophozoite and schizont |
| of dolichol and ubiquinones by degradation of 3-hydroxy-3-methylglutaryl-Co A reductase (3). |
| Age-associated increase of free dolichol levels in mice. (179 words) |
| Free dolichol levels were determined by high-performance liquid chromatography in liver, brain, heart, lung, testis and kidney of C57 B1/6 mice at 3, 6, 12 and 30 months of age. |
| The largest increase in dolichol was in testis and the smallest increase was in the liver. |
| The major dolichols among the various tissues were of the 17, 18, 19 and 20 isoprene unit containing types and the proportions were unaffected by aging. |
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