Doramectin plasma concentrations increased during the course of the study in the 30 and 40 mg/kg bw/day groups, attaining levels of 4.6 and 5.8 µg/ml, respectively.
The oral bioavailability of doramectin in rats, as measured by the plasma concentration of the drug and the area under the plasma concentration-time curve, was approximately six times greater when doramectin was administered in sesame oil as compared to an aqueous vehicle or in the diet.
Doramectin was shown to be readily excreted in the milk of lactating rats following administration by gavage and, as compared with adult animals, higher drug levels were attained in the brain of neonates, suggesting greater penetration through the incompletely formed blood-brain barrier in newborn rats.
Doramectin is not approved for use in female dairy cattle 20 months of age or older.
If a lactating cow is exposed to doramectin, milk from the cow may have detectable residues of the drug for as long as 60 days.
Doramectin (NADA 141-095) is approved for topical use to treat and control various worms (roundworms, lungworms, and eyeworms), grubs, lice, horn flies, and mange mites.
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