It has been suggested that effective dose be merged into this article or section. (Discuss) The Dose-response relationship describes the change in effect on an organism caused by differing levels of exposure (or doses) to a substance. This may apply to individuals (eg: a small amount has no observable effect, a large amount is fatal), or to populations (eg: how many people are affected at different levels of exposure). Image File history File links Please see the file description page for further information. ...
Effective dose is a measure used in radiation protection to estimate the risk resulting from an exposure of radiation. ...
A crab is an example of an organism. ...
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Dose can refer to several things: n An amount of medication to be taken at one time. ...
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Studying dose response, and developing dose response models, is central to determining "safe" and "hazardous" levels and dosages for drugs, potential pollutants, and other substances that humans are exposed to. These conclusions are often the basis for public policy. A psychoactive drug or psychotropic substance is a chemical substance that acts primarily upon the central nervous system where it alters brain function, resulting in temporary changes in perception, mood, consciousness and behavior. ...
Human beings are defined variously in biological, spiritual, and cultural terms, or in combinations thereof. ...
When the agent is radiation instead of a drug, this is called the exposure-response relationship. Radiation in Physics is the process of emitting energy in the form of waves or particles. ...
Dose-response curve
A dose-response curve is a simple X-Y graph relating the amount of a drug or toxin given to the response of the organism to that drug. The curves are usually qualitative, though they can use quantitative information. Fig. ...
Qualitative is an important qualifier in the following subject titles: Qualitative identity Qualitative marketing research Qualitative method Qualitative research THE BIG J This is a disambiguation page — a list of pages that otherwise might share the same title. ...
A scale for measuring mass A quantitative property is one that exists in a range of magnitudes, and can therefore be measured. ...
The measured dose (usually in [[milligrams, micrograms, or grams per kilogram of body-weight) is generally plotted on the X axis and the response is plotted on the Y axis. Commonly, it is the logarithm of the dose that is plotted on the X axis, and in such cases the curve is typically sigmoidal, with the steepest portion in the middle. Dose can refer to several things: n An amount of medication to be taken at one time. ...
The microgram (symbol µg, sometimes mcg) is an SI unit of mass. ...
For other meanings of gram, see gram (disambiguation). ...
Logarithms to various bases: is to base e, is to base 10, and is to base 1. ...
The logistic function or logistic curve is defined by the mathematical formula: for real parameters a, m, n, and . ...
The first point along the graph where a response above zero is reached is usually referred to as a threshold-dose. For most beneficial or recreational drugs, the desired effects are found at doses slightly greater than the threshold dose. At higher doses still, undesired side effects appear and grow stronger as the dose increases. The stronger a particular substance is, the steeper this curve will be. In quantitative situations, the Y-axis usually is designated by percentages, which refer to the percentage of users registering a standard response (which is often death, when the 50% mark refers to LD50). An LD50 test being administered In toxicology, the LD50 or colloquially semilethal dose of a particular substance is a measure of how much constitutes a lethal dose. ...
Problems exist regarding non-linear relationships between dose and response, thresholds reached and 'all-or-nothing' responses. These inconsistencies can challenge the validity of judging causality solely by the strength or presence of a dose-response relationship.
See also Pharmacodynamics is the study of the biochemical and physiological effects of drugs and the mechanisms of drug action and the relationship between drug concentration and effect. ...
Spatial epidemiology is the study of the spatial distribution of disease. ...
The term EC50 represents the concentration of a compound where 50% of its effect is observed. ...
The term IC50 represents the concentration of an inhibitor that is required for 50% inhibition of things like an enzyme, a cell receptor or a microorganism. ...
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