The title Earl of Bothwell has been created twice in the Peerage of Scotland. It was first created for Patrick Hepburn in 1488, and was forfeited in 1567. It was then created for Francis Stewart in 1587. The second creation was forfeited in 1612.

The title Duke of Orkney was created in the Peerage of Scotland in 1567 for James Hepburn, 4th Earl of Bothwell, with the subsidiary title Marquess of Fife. All titles were declared forfeit in 1567.

Earls of Bothwell, first creation (1488)

• Patrick Hepburn, 1st Earl of Bothwell (d. 1508)
• Adam Hepburn, 2nd Earl of Bothwell (1492-1513)
• Patrick Hepburn, 3rd Earl of Bothwell (d. 1556)
• James Hepburn, 4th Earl of Bothwell (1535-1578) became Duke of Orkney in 1567

Duke of Orkney (1567)

• James Hepburn, 1st Duke of Orkney (1535-1578)

Earls of Bothwell, second creation (1587)

• Francis Stewart Hepburn, 1st Earl of Bothwell (1563-1612)