Dynorphin (Dyn) is a popular and powerful opioidligand. It may act as an antidote to pleasurable effects of cocaine. As such, it may help some individuals against the trap of addiction. Blocking it may help alleviate depression. Dynorphin is classified as a kappa opioid receptor agonist. Opium is a narcotic drug which is obtained from the unripe seed pods of the opium poppy . ... In chemistry, a ligand is an atom, ion or functional group that is bonded to one or more central atoms or ions, usually metals generally through co-ordinate covalent bond. ... Cocaine is a crystalline alkaloid that is obtained from the leaves of the coca plant. ... Addiction is an uncontrollable compulsion to repeat a behavior regardless of its consequences. ... Clinical Depression is a health condition of depression with mental and physical components reaching criteria generally accepted by clinicians. ...
References
"Stabilized Dynorphin Derivatives for Modulating Antinociceptive Activity in Morphine Tolerant Rats: Effect of Different Routes of Administration (http://www.aapsj.org/view.asp?art=aapsj060436)." American Association of Pharmaceutical Scientists Journal. Accessed on March 4, 2005. "Dynorphin and Depression (http://opioids.com/dynorphin/depression.html)." Opioids.com. Accessed on March 4, 2005. "Dynorphin: Nature's Own Antidote to Cocaine (and Pleasure?) (http://dynorphin.com/)." dynorphin.com. Accessed on March 4, 2005. March 4 is the 63rd day of the year in the Gregorian Calendar (64th in leap years). ... 2005 is a common year starting on Saturday of the Gregorian calendar and is the current year. ... March 4 is the 63rd day of the year in the Gregorian Calendar (64th in leap years). ... 2005 is a common year starting on Saturday of the Gregorian calendar and is the current year. ... March 4 is the 63rd day of the year in the Gregorian Calendar (64th in leap years). ... 2005 is a common year starting on Saturday of the Gregorian calendar and is the current year. ...
Dynorphin is a member of the body's natural, or endogenous, opioid system.
Furthermore, Kreek and her colleagues have demonstrated directly in rats and indirectly in humans that administration of dynorphin results in a decrease in the amount of dopamine in the brain.
Together, these studies imply that dynorphin rises after cocaine administration as a means to counteract the effects of cocaine.