The Duke of Roxburghe (pronounced "Roxbruh") is a title in the peerage of Scotland created in 1707 along with the titles Viscount Broxmouth, Marquess of Bowmont and Cessford and Earl of Kelso. John Ker, 5th Earl of Roxburghe became the first holder of these titles.

The Duke has the subsidiary titles of: Marquess of Bowmont and Cessford (created 1707), Earl of Roxburghe (1616), Earl of Kelso (1707), Earl Ker (1722), Earl Innes (1837), Viscount Broxmouth (1707), Lord Roxburghe (1600), Lord Ker of Cessford and Cavertoun (1616) and Baron Ker of Wakefield (1722). Most of the titles form part of the peerage of Scotland, but the Earldom of Ker and the Barony of Ker of Wakefield belong to the peerage of Great Britain, and the Earldom of Innes to the United Kingdom peerage. The Duke's eldest son bears the courtesy title of Marquess of Bowmont and Cessford.

The family has its seat at Floors Castle in Kelso, Scotland.

Earls of Roxburghe (1616)

• Robert Ker, 1st Earl of Roxburghe (1570-1650)
• William Ker, 2nd Earl of Roxburghe (d. 1675)
• Robert Ker, 3rd Earl of Roxburghe (c. 1658-1682)
• Robert Ker, 4th Earl of Roxburghe (d. 1696)
• John Ker, 5th Earl of Roxburghe (became Duke of Roxburghe in 1707) (c. 1680-1741)

Dukes of Roxburghe (1707)

• John Ker, 1st Duke of Roxburghe (c. 1680-1741)
• Robert Ker, 2nd Duke of Roxburghe (c. 1709-1755)
• John Ker, 3rd Duke of Roxburghe (1740-1804)
• William Ker, 4th Duke of Roxburghe (1728-1805)
• James Innes-Ker, 5th Duke of Roxburghe (1736-1823)
• James Innes-Ker, 6th Duke of Roxburghe (1816-1879)
• James Innes-Ker, 7th Duke of Roxburghe (1839-1892)
• Henry John Innes-Ker, 8th Duke of Roxburghe (1876-1932)
• George Innes-Ker, 9th Duke of Roxburghe (1913-1974)
• Guy David Innes-Ker, 10th Duke of Roxburghe (b. 1954)

his son and heir: Charles Robert George Innes-Ker, Marquess of Bowmont and Cessford (b. February 18, 1981)