He married Elizabeth Hastings and had four children:
Henry Somerset, 5th Earl of Worcester, his heir and successor, who was later created the 1st Marquess of Worcester;
Thomas Somerset, 1st Viscount Somerset (Peerage of Ireland), who was born in 1579, died in 1649; he was created Viscount Somerset on December 8, 1626; in 1616 he married Helen Barry - her third marriage -, with whom he had one daughter:
Elizabeth Somerset, who might have died young, but that is unsure;
Lady Catherine or Katherine Somerset, who died on November 6, 1654 and, before January 14, 1607, married Thomas Windsor, 6th Baron Windsor, with whom she had no issue; and
Lady Blanche Somerset, who died October 28, 1649, and married Thomas Arundell, 2nd Baron Arundell, with whom she had one son and two daughters, his only children; the settlement for this marriage was on May 11th, 1607.