Dr. Edwin Bennett Astwood (December 19, 1909 - February 17, 1976) was a Bermudan-Americanphysiologist and endocrinologist, his research on endocrine system led to treatments for hyperthyroidism. December 19 is the 353rd day of the year (354th in leap years) in the Gregorian calendar. ... 1909 was a common year starting on Friday (see link for calendar). ... February 17 is the 48th day of the year in the Gregorian calendar. ... 1976 is a leap year starting on Thursday (link will take you to calendar). ... Bermuda is an internally self-governing island Overseas Territory of the United Kingdom, situated in the Atlantic Ocean. ... Physiology (in Greek physis = nature and logos = word) is the study of the mechanical, physical, and biochemical functions of living organisms. ... Endocrinology is a branch of medicine dealing with disorders of the endocrine system and its specific secretions called hormones. ... Major endocrine glands. ... Hyperthyroidism (thyrotoxicosis or fast thyroid gland) is the clinical syndrome caused by an excess of circulating free thyroxine (T4) and free triiodothyronine (T3), or both. ...
Reference
Cooper, D. Y. Astwood, Edwin Bennett. American National Biography Online Feb. 2000.
October 1972 Christian B. Anfinsen, chief of the institute's Laboratory of Chemical Biology, shared a Nobel Prize with two other American scientists for his demonstration of one of the most important simplifying concepts of molecular biology, that the three-dimensional conformation of a native protein is determined by the chemistry of its amino acid sequence.
Edwin G. Krebs and Edmond H. Fischer were awarded the Nobel Prize in Physiology or Medicine for their work on "reversible protein phosphorylation." They have received grant support from NIDDK since 1955 and 1956, respectively.
b) Research that seeks the elucidation of molecular structures or biological pathways that may lead to the identification and validation of targets that can be potentially manipulated by ligands/inhibitors.