With her sisters, Elizabeth de Clare and Margaret de Clare, she inherited her father's estates after the death of her brother, Gilbert de Clare, 4th Earl of Gloucester.
She was born at Caerphilly, Glamorgan, and married, at Westminister, shortly after 14 June 1306, Hugh the younger Despenser, of Hanley Castle, the son of Hugh leDespenser, Earl of Winchester by Isabel Beauchamp, daughter of William de Beauchamp, 9th Earl of Warwick.
Hugh leDespenser was executed, and she was imprisoned in 1326.