It is the primary thesis of this paper that the empathogenic substances induce an experience that has the potential for dissolving the defensive intrapsychic separation between spirit, mind, and body, and that therefore physical healing, psychological problem solving, and spiritual awareness can and usually do co-occur in the same experience.
Perceptual changes with the empathogenics are usually minimal, but a deep feeling of appreciation for and connectedness with all life forms is often reported in such sessions.
Empathogenics are a subcategory of psychedelic ("mind- manifesting") drugs, such as LSD and psilocybin.
The term "empathogen" to describe MDMA and other closely related phenethylamine "empathy drugs" [MDA, MDEA, MBDB] was proposed by Ralph Metzner, Dean of the California Institute of Integral Studies, at a 1983 conference at the University of California at Santa Barbara.
The term "entactogen" was coined in 1986 by Dr David Nichols, Professor of Medicinal Chemistry and Pharmacology at Purdue University and co-founder of the Heffter Research Institute, to refer to substances that generate a sense of "touching within" or "produce a feeling in one's innermost being".
This is because a sustained regimen of SSRIs largely blunts MDMA's empathogenic and entactogenic effects.