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Encyclopedia > Enbrel

Etanercept (EnbrelŪ, co-marketed by Amgen and Wyeth) is a recombinant human soluble tumor necrosis factor-alpha (TNFα) receptor. It is a small protein (p75, i.e., its molecular weight is 75 kDa) that binds TNFα and decreases its role in inflammatory diseases such as rheumatoid arthritis, Crohn's disease, psoriasis, psoriatic arthritis, and ankylosing spondylitis. It was released soon after infliximab, a monoclonal antibody with anti-TNFα activity, but etanercept is generally tolerated better and does not seem to cause reactivation of tuberculosis.


External links

  • http://www.enbrel.com/

  Results from FactBites:
 
Enbrel, Etanercept, side effects, drug interactions, overdose, dosage (950 words)
Enbrel is used to relieve the symptoms and slow the progress of moderate to severe rheumatoid arthritis.
Enbrel is the first in a class of drugs designed to block the action of tumor necrosis factor (TNF), a naturally occurring protein responsible for much of the joint inflammation that plagues the victims of rheumatoid arthritis.
Enbrel is also used to reduce the symptoms of active ankylosing spondylitis, an inflammatory condition that results in stiffness and immobility and can sometimes cause joints and bones to fuse together.
  More results at FactBites »


 

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