An endergonic reaction is a chemical reaction in which the change in free energy is positive. An endergonic reaction is a reaction in which ΔG > 0 in Gibbs free energy, in contrast to an exothermic reaction, which uses ΔH as in enthalpy. Examples of endergonic reactions in cells include protein synthesis, nerve conduction, and muscle contraction. In thermodynamics, free energy is a measure of the amount of work that can be extracted from a system. ... In thermodynamics the Gibbs free energy is a state function of any system defined as where G is the Gibbs free energy, measured in joules H is the enthalpy, measured in joules T is the temperature, measured in kelvins S is the entropy, measured in joules per kelvin... In chemistry, an exothermic reaction is one that releases heat. ... Enthalpy (symbolized H, also called heat content) is the sum of the internal energy of matter and the product of its volume multiplied by the pressure. ...