The endocannabinoid system (also endogenous cannabinoid system) consists of two transmembranecannabinoid receptors, endogenous cannabinoids, a transporter protein (anandamide transporter), and the metabolic enzymes inactivating the endocannabinoids (MGL and FAAH). The CB1 receptors are present in many central and peripheral sites involved in the control of homeostasis [1]. CB2 receptors are primarily expressed in peripheral and immune tissues. The main endogenous cannabinoids are anandamide and 2-arachidonylglycerol. The Endogenous cannabinoid system affect a large number of physiologic processes including: feeding behavior, pain perception, motor control, memory and learning, immune and inflammatory responses, neuroprotection and intraocular pressure [1]. Transmembrane receptors are integral membrane proteins, which reside and operate typically within a cells plasma membrane, but also in the membranes of some subcellular compartments and organelles. ... The cannabinoid receptors are a class of receptors under the G-protein coupled receptor superfamily. ... ... Motto: Dayar Mongol Anthem: National Anthem of Mongolia Capital Ulaanbaatar Largest city Ulaanbaatar Official language(s) Mongolian Government President Prime minister Parliamentary democracy Nambaryn Enkhbayar Miyeegombyn Enkhbold Independence - Declared July 11, 1921 Area • Total • Water (%) 1,564,116 km² (18th) 0. ... It has been suggested that Fatty acyl amide hydrolase be merged into this article or section. ... Anandamide, also known as arachidonoylethanolamine or AEA, is a naturally occurring endogenous cannabinoid neurotransmitter found in the brain of animals, as well as other organs. ... Image:2-AG.png 2-Arachidonoylglycerol 2-Arachidonoylglycerol (2-AG) is an endogenous agonist of the CB1 receptor. ...
External links
The Endocannabinoid System Network (ECSN) - A CME source about the Endocannabinoid System
References
Lambert, D. M.; Fowler, C. J. 2005. The Endocannabinoid System: Drug Targets, Lead Compounds, and Potential Therapeutic Applications J. Med. Chem. 48(16):5059-5087
The EndocannabinoidSystem (EC System) is a physiological system of cannabinoid receptors and corresponding chemical messengers that is believed to play an important role in regulating body weight and glucose and lipid metabolism.
Its activity is up-regulated and it is converted from a system that is intermittently transiently activated, to one that is chronically overactivated.
The chronic consumption of nicotine permanently over-stimulates the EC System in the nucleus accumbens shell, with subsequent reinforcement of dopamine release and nicotine abuse.
The endocannabinoidsystem is constituted of cannabinoid receptors, endogenous cannabinoids, and the molecules involved in the inactivation of endocannabinoids (uptake and degradation enzyme known as fatty acid amide hydrolase, FAAH).
The further evidence for the participation of the endocannabinoidsystem in alcohol drinking behavior is derived from the observed differences in CB1 receptor function in two genetic strains of alcohol-preferring C57BL/6 and alcohol-avoiding DBA/2 mice.
Thus genetically determined differences in the activities of distinct components of the endocannabinoidsystem under basal conditions or in response to alcohol exposure may exist between alcohol-preferring and alcohol-avoiding animals and may be partially responsible for the differences in their voluntary alcohol intake.
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