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| | Enoxaparin | | Systematic (IUPAC) name | | 6-[5-acetylamino-4,6-dihydroxy-2- (sulfooxymethyl)tetrahydropyran-3-yl] oxy-3- [5-(6-carboxy-4,5-dihydroxy-3- sulfooxy-tetrahydropyran-2-yl)oxy-6-(hydroxymethyl)- 3-sulfoamino-4-sulfooxy-tetrahydropyran-2-yl] oxy-4-hydroxy-5-sulfooxy-tetrahydropyran-2- carboxylicacid | | Identifiers | | CAS number | 9005-49-6 | | ATC code | B01AB05 | | PubChem | 772 | | DrugBank | APRD00068 | | Chemical data | | Formula | (C26H40N2O36S5)n | | Mol. mass | 4500 daltons (average) | | Pharmacokinetic data | | Bioavailability | 92% | | Protein binding | 80% bound-albumin | | Metabolism | primarily by liver by desulfation and/or depolymerization | | Half life | 4.5 hours | | Excretion | ? | | Therapeutic considerations | | Pregnancy cat. | B Image File history File links Enoxaparin. ...
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| | Legal status | | | Routes | Subcutaneous (SC) Injection and intervenous (IV) per package insert | Enoxaparin is a low molecular weight heparin manufactured by Sanofi-Aventis. It is marketed as Lovenox or Clexane. Enoxaparin injections are derived from the intestinal mucosa of pigs. Enoxaparin is used to prevent and treat deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection (by a health care provider or the patient). Its use is evolving in acute coronary syndromes. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ...
In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ...
In medicine, low molecular weight heparin (LMWH) is a class of medication used as an anticoagulant in diseases that feature thrombosis, as well as for prophylaxis in situations that lead to a high risk of thrombosis. ...
Sanofi-aventis (Euronext: SAN, NYSE: SNY), headquartered in Paris, France, is one of the 3 largest pharmaceutical companies in the world, along with Pfizer,GlaxoSmithKline. ...
This article is about Deep-vein thrombosis. ...
The subcutis is the layer of tissue directly underlying the cutis. ...
An acute coronary syndrome (ACS) is a set of signs and symptoms suggestive of sudden cardiac ischemia, usually caused by disruption of atherosclerotic plaque in an epicardial coronary artery. ...
In the UK, enoxaparin is approved for five indications:
In the United States, enoxaparin is FDA approved for eight indications: Thrombosis is the formation of a clot or thrombus inside a blood vessel, obstructing the flow of blood through the circulatory system. ...
Orthopedic surgery or orthopedics (BE: orthopaedics) is the branch of surgery concerned with acute, chronic, traumatic and recurrent injuries and other disorders of the locomotor system, its musclular and bone parts. ...
A venous thrombosis is a blood clot that forms within a vein. ...
Illness (sometimes referred to as ill-health) can be defined as a state of poor health. ...
This article is about Deep-vein thrombosis. ...
angina tonsillaris see tonsillitis. ...
Acute myocardial infarction (AMI or MI), more commonly known as a heart attack, is a disease state that occurs when the blood supply to a part of the heart is interrupted. ...
Aspirin, or acetylsalicylic acid (IPA: ), (acetosal) is a drug in the family of salicylates, often used as an analgesic (to relieve minor aches and pains), antipyretic (to reduce fever), and as an anti-inflammatory. ...
In medicine, dialysis is a method for removing waste such as urea from the blood when the kidneys are incapable of this, i. ...
- Prophylaxis of DVT in medically ill patient,
- Total hip & knee replacement,
- Extended hip-replacement,
- Abdominal surgery.
- Treatment of DVT with or with out PE inpaient and
- Treatment of DVT inpatient, ACS and STEMI.
Mechanism of action
Enoxaparin binds to and accelerates the activity of antithrombin III. By activating antithrombin III, enoxaparin preferentially potentiates the inhibition of coagulation factors Xa and IIa. The anticoagulant effect of enoxaparin can be directly correlated to its ability to inhibit factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, so enoxaparin’s inhibition of this process results in decreased thrombin and ultimately the prevention of fibrin clot formation. Factor X, also known by the eponym Stuart-Prower factor or as thrombokinase, is an enzyme (EC 3. ...
Thrombin (activated Factor II) is a coagulation protein that has many effects in the coagulation cascade. ...
Fibrin is a protein involved in the clotting of blood. ...
Monitoring - INR, PT, CBC with platelets, aPTT (not as useful as in heparin). Enoxaparin does not affect the INR, PT or aPTT per the package insert
- Anti-factor Xa levels can be measured, and are sometimes used to monitor enoxaparin activity in patients with renal insufficiency.
Pregnancy
Side effects For other uses, see Bleeding (disambiguation). ...
Thrombocytopenia (or -paenia, or thrombopenia in short) is the presence of relatively few platelets in blood. ...
Heparin-induced thrombocytopenia (HIT) with or without thrombosis (HITT) is thrombocytopenia (low platelet counts) due to the administration of heparin. ...
“Hurting†redirects here. ...
A bruise or contusion or ecchymoses is a kind of injury, usually caused by blunt impact, in which the capillaries are damaged, allowing blood to seep into the surrounding tissue. ...
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A nodule describes an aggregation of similar cells or particles in a number of scientific fields: In medicine it refers to a small aggregation of cells. ...
A rash is a change in skin which affects its color, appearance or texture. ...
An injection is a method of putting liquid into the body with a hollow needle and a syringe which is pierced through the skin long enough for the material to be forced into the body. ...
For the play, see Hay Fever. ...
The abdomen is a part of the body. ...
Male Chest The chest is a part of the anatomy of humans and various other animals. ...
A headache (cephalalgia in medical terminology) is a condition of pain in the head; sometimes neck or upper back pain may also be interpreted as a headache. ...
Reversal Agent - Protamine, although not as effective at reversal as it is for heparin due to more activity at the Xa clotting factor (enoxaparin); as heparin has both Xa and IIa. Protamine sulfate will reverse enoxaparin by 66% per package insert.
Protamine is a drug that reverses the anticoagulant effects of heparin by binding to it. ...
Availability 100 mg/mL - Prefilled Syringes: 30mg/0.3mL, 40mg/0.4mL
- Graduated Prefilled Syringes: 60mg/0.6mL, 80mg/0.8mL, 100mg/1mL
- Multiple Dose Vials: 300mg/3.0mL
150mg/mL - Graduated Prefilled Syringes: 120mg/0.8mL, 150mg/1mL
External links - DrugBank Information
- Sanofi-Aventis information
- Lovenox: Prescribing Information
| Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01) | | Vitamin K antagonists | Acenocoumarol • Clorindione • Coumatetralyl • Dicumarol (Dicoumarol) • Diphenadione • Ethyl biscoumacetate • Phenprocoumon • Phenindione • Tioclomarol • Warfarin | | Heparin group | Antithrombin III • Danaparoid • Heparin • Sulodexide • low molecular weight heparin (Bemiparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin) | | Glycoprotein IIb/IIIa inhibitors | Abciximab • Eptifibatide • Tirofiban | Other platelet
aggregation inhibitors | Acetylsalicylic acid/Aspirin • Aloxiprin • Ditazole • Carbasalate calcium • Cloricromen • Clopidogrel • Dipyridamole • Indobufen • Picotamide • Prasugrel • Ticlopidine • Triflusal • prostaglandin analogue (Beraprost, Prostacyclin, Iloprost, Treprostinil) | | Enzymes | plasminogen activators (Alteplase/Reteplase/Tenecteplase, Streptokinase, Urokinase/Saruplase, Anistreplase) • other serine endopeptidases (Ancrod, Drotrecogin alfa/Protein C, Fibrinolysin) • Brinase | | Direct thrombin inhibitors | Argatroban • Bivalirudin • Dabigatran • Desirudin • Hirudin • Lepirudin • Melagatran • Ximelagatran | | Other antithrombotics | Defibrotide • Dermatan sulfate • Fondaparinux • Rivaroxaban | | Non-medicinal | Citrate • EDTA • Oxalate | |
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