In 2375, the Enterprise-E prevented an attempted relocation of the Ba'ku people from their homeworld in the Briar Patch (an unstable, colourful region of space full of false vacuum fluctuations, nebulas, metreon gas clouds, plasma fields, numerous supernova remnants, and unusual space anomalies) of Federation Space by the Son'a, an offshoot of the Ba'ku that left the homeworld a century earlier; the events of Star Trek: Insurrection.
Four years later the Enterprise-E was featured in Star Trek: Nemesis, when a renegade clone of Jean-Luc Picard took control of the Romulan Star Empire and threatened the destruction of Earth. During this mission, the Enterprise-E took heavy damage (including having its bridge exposed to space), requiring extensive refitting afterwards.
Due to the fact that this Enterprise was launched and commissioned so quickly following the events of Star Trek: Generations and the destruction of the Enterprise-D many fans speculated that this ship was originally a different vessel which was hastily renamed 'Enterprise'. However, this has neither been substantially confirmed or denied by any canon Star Trek film or show.