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Escitalopram oxalate (also known as LexaproTM and CipralexTM) is a medication developed by the Danish pharmaceutical company Lundbeck, that acts as a selective serotonin reuptake inhibitor or SSRI. It is typically used as an antidepressant to treat depression associated with mood disorders although also may be used in the treatment of body dysmorphic disorder and anxiety. IUPAC nomenclature is a systematic way of naming organic chemical compounds as recommended by the International Union of Pure and Applied Chemistry (IUPAC). ...
CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ...
The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ...
A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ...
The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ...
In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ...
The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ...
--212. ...
The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ...
The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ...
H. Lundbeck A/S (also known as Lundbeck) is a Danish international pharmaceutical company engaged in the research and development, production, marketing and sale of drugs for the treatment of psychiatric and neurological disorders. ...
Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants. ...
An antidepressant is a medication designed to treat or alleviate the symptoms of clinical depression; antidepressants function generally by interacting with the neurotransmitters (signalling chemicals) in the brain believed to influence mood. ...
Clinical depression is a health condition of depression with mental and physical components reaching criteria generally accepted by clinicians. ...
A mood disorder is a condition where the prevailing emotional mood is distorted or inappropriate to the circumstances. ...
Body dysmorphic disorder (BDD) is a mental disorder which involves a disturbed body image. ...
It has been suggested that anxiety disorder be merged into this article or section. ...
Escitalopram is the pure S-enantiomer (single isomer) of the racemic bicyclic phthalane derivative citalopram. Escitalopram oxalate is designated S-(+)-1-[3-(dimethylamino)propyl]-1-( p -fluorophenyl)-5-phthalancarbonitrile oxalate with the molecular formula: In chemistry two stereoisomers are said to be enantiomers if they are mirror images of each other. ...
In chemistry, isomers are molecules with the same chemical formula and often with the same kinds of bonds between atoms, but in which the atoms are arranged differently. ...
In chemistry, a racemate is a mixture of equal amounts of left- and right-handed stereoisomers of a chiral molecules. ...
C20H22FN2O+ C2HO4- and the molecular weight is 414.40.
Escitalopram oxalate is derived from the drug citalopram which is made up of two mirror-image isomers, only one of which is thought to be an effective medication. Lundbeck has split the isomers apart, taken the active isomer and has licensed it as the new drug 'escitalopram'. Citalopram or nitalapram is an antidepressant drug used to treat the depression associated with mood disorders. ...
In chemistry, isomers are molecules with the same chemical formula and often with the same kinds of bonds between atoms, but in which the atoms are arranged differently. ...
It is notable that escitalopram was released shortly before the patent for citalopram was due to expire. The expiration of a patent means other companies can legally produce cheaper generic versions. Escitalopram is subject to a new patent. Critics have argued that escitalopram, and the subsequent marketing campaign to persuade mental health professionals to prescribe it, is a cynical ploy to promote sales of a virtually identical but considerably more expensive drug. In defence of the new drug, Lundbeck have claimed that the drug has additional benefits over the older citalopram and other antidepressant drugs on the market. A patent is a set of exclusive rights granted by a state to a person for a fixed period of time in exchange for the regulated, public disclosure of certain details of a device, method, process or substance (known as an invention) which is new, inventive and useful. ...
A generic drug is a drug which is bioequivalent to a brand name drug with respect to pharmacokinetic and pharmacodynamic properties, but is normally sold for a lower price. ...
In the United States, the drug is marketed under the name LexaproTM by Forest Laboratories, Inc.
In Canada, the drug is marketed under the name Cipralex TM by Lundbeck Canada, Inc.
Externals links
- Lexapro Information FAQ to Lexapro
- Pharmacological information Lexapro
- Lexapro Feedback Depression Blog
This article needs to be cleaned up to conform to a higher standard of quality. ...
| Antidepressants edit | | Dopamine reuptake inhibitors edit | | {Bupropion} An antidepressant is a medication designed to treat or alleviate the symptoms of clinical depression; antidepressants function generally by interacting with the neurotransmitters (signalling chemicals) in the brain believed to influence mood. ...
Dopamine reuptake inhibitors are compounds that increase amounts of the neurotransmitter dopamine in the brain by inhibiting its reuptake at synapses. ...
Bupropion (amfebutamone) is an antidepressant of the aminoketone class, chemically unrelated to tricyclics or SSRIs. ...
| | | Norepinephrine reuptake inhibitors edit | | {Atomoxetine} {Reboxetine} Norepinephrine reuptake inhibitors (NRIs) are compounds that increase amounts of the neurotransmitter norepinephrine in the brain by inhibiting its reuptake at synapses. ...
Atomoxetine hydrochloride is a prescription drug used in the treatment of attention-deficit hyperactivity disorder (ADHD). ...
Reboxetine is an antidepressant drug used in the treatment of clinical depression, panic disorder and ADD/ADHD. Its mesilate ( methanesulfonate) salt is sold under tradenames including Edronax®, Norebox®, Prolift® or Vestra®. Chemically it is (±)-(2R*)-2-[(αR*)-α-(o-ethoxyphenoxy)benzyl]morpholine. ...
| | | Monoamine oxidase inhibitors edit | | {Ayahuasca} {Nialamide} {Selegiline} {Isocarboxazid} {Moclobemide} {Phenelzine} {Tranylcypromine} Monoamine oxidase inhibitors (MAOIs) are a class of antidepressant drugs prescribed for the treatment of depression. ...
The widely used Quechuan name Ayahuasca has two highly interrelated yet distinct meanings and referents: 1) an Amazonian giant vine native to the rainforest, generally Banisteriopsis caapi, and, by extension, 2) pharmacologically complex infusions prepared from it for shamanic, folk-medicinal, and neo-religious purposes. ...
Nialamide (Espril®, Niamid®, Niaquitil®, Nuredal®, Nyazin®, and Psicodisten®) was one of the first MAOI (monoamine oxidase inhibitor) antidepressants. ...
Selegiline/l-Deprenyl Selegiline (l-deprenyl, Eldepryl® or Anipryl® [veterinary]) is a drug used for the treatment of early-stage Parkinsons disease and senile dementia. ...
Isocarboxazid is a nonselective hydrazine-derived monoamine oxidase inhibitor used in treatment resistant depression. ...
// Description Moclobemide (Aurorix, Manerix) is a psychiatric drug. ...
Phenelzine is an antidepressant drug that belongs to the monoamine oxidase inhibitor class of drugs. ...
Tranylcypromine is an antidepressant drug. ...
| | | Selective serotonin reuptake inhibitors edit | | {Zimelidine} {Citalopram (Cipramil/Celexa)} {Escitalopram oxalate (Lexapro)} {Fluoxetine (Prozac)} {Fluvoxamine maleate (Faverin)} {Paroxetine (Paxil)} {Sertraline (Zoloft)} Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants. ...
Zimelidine was the first SSRI antidepressant. ...
Citalopram or nitalapram is an antidepressant drug used to treat the depression associated with mood disorders. ...
Fluoxetine hydrochloride is an antidepressant drug used medically in the treatment of depression, obsessive-compulsive disorder, bulimia nervosa, premenstrual dysphoric disorder and many other disorders. ...
Fluvoxamine maleate (sold under the brand-names Luvox® and Faverin®) is a selective serotonin reuptake inhibitor. ...
Paroxetine or paroxetine hydrochloride (sold under the trade names Paxil® in the United States, Seroxat® in the UK and China, Aropax® in Australia and New Zealand, Deroxat in Switzerland) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) type. ...
Sertraline hydrochloride (Zoloft®, Lustral®, Apo-Sertral®, Asentra®, Gladem®, Serlift®, Stimuloton®, Xydep®) is an orally administered antidepressant of the selective serotonin reuptake inhibitor (SSRI) type. ...
| | | Serotonin-norepinephrine reuptake inhibitors [ ] | | {Desipramine} {Duloxetine} {Milnacipran} {Nefazodone} Serotonin norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant used in the treatment of clinical depression and other affective disorders. ...
Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. ...
Duloxetine hydrochloride (brand name: Cymbalta) is a medically used drug that primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). ...
Milnacipran is an antidepressant of the serotonin-norepinephrine reuptake inhibitor class. ...
// Introduction Serzone (nefazodone) Serzone ( Nefazodone HCl ) is an antidepressant drug formerly marketed by Bristol-Myers Squibb. ...
| | | Bicyclic antidepressants edit | | {Viloxazine} {Venlafaxine} Viloxazine is a bicyclic antidepressants[2] that inhibits the reuptake of serotonin, and to a lesser extent, dopamine and norepinephrine. ...
Venlafaxine hydrochloride is a synthetic derivative of phenethylamine and a prescription antidepressant first introduced by Wyeth in 1993, and marketed under the trade names Effexor® for tablets and Effexor XR® for extended-release capsules. ...
| | | Tetracyclic antidepressants [ ] | | {Maprotiline} {Mianserin} {Mirtazapine} Categories: Stub | Antidepressants ...
Categories: Stub | Norepinephrine reuptake inhibitors | Tetracyclic antidepressants ...
Mirtazapine is a prescription antidepressant introduced by Organon in 1996, and marketed under the tradename Remeron® (also: Zispin®, Avanza®, Norset®, Remergil®). It is used primarily for the treatment of clinical depression in adults. ...
| | | Selective serotonin reuptake enhancers edit | | {Tianeptine} Tianeptine (INN), is structurally similar to the tricyclic antidepressants. ...
| | | Tricyclic antidepressants [ ] | | {Amitriptyline} {Amoxapine} {Clomipramine} {Desipramine} {Dothiepin} {Doxepin} {Imipramine} {Nortriptyline} {Protriptyline} {Trimipramine} Chemical structure of the tricyclic antidepressant amitriptyline Tricyclic antidepressants are a class of antidepressant drugs first used in the 1950s. ...
Amitriptyline hydrochloride is an antidepressant drug from the tricyclic antidepressant group, which is sold under the trade names Elavil®, Tryptanol® or Endep®. Its full chemical name is 3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride and its empirical formula is C20H23N...
Amoxapine (Asendin®; Asendis®; Defanyl®; Demolox®; Moxadil®) is a tricyclic antidepressant of the dibenzoxazepine class. ...
Clomipramine is a Tricyclic antidepressant. ...
Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. ...
Doxepin, is a tricyclic antidepressant and is used to treat depression and anxiety. ...
Imipramine (tradenames: Janimine®, Tofranil®) is an antidepressant medication belonging to a class called tricyclic antidepressants of the dibenzazepine group, mainly used in the treatment of clinical depression and enuresis. ...
Nortriptyline is a tricyclic antidepressant marketed under the tradenames Aventyl® and Pamelor®. It is used to treat depression. ...
Trimipramine is a antidepressant drug with sedative properties. ...
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