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Encyclopedia > Estrone
Estrone chemical structure
Estrone
Systematic (IUPAC) name
3-hydroxy-13-methyl- 6,7,8,9,11,12,13,14,15,16- decahydrocyclopenta[a]phenanthren- 17- one
Identifiers
CAS number 53-16-7
ATC code G03CA07 G03CC04
PubChem 5870
DrugBank APRD00588
Chemical data
Formula C18H22O2
Mol. weight 270.366 g/mol
Physical data
Melt. point 254.5 °C (490 °F)
Pharmacokinetic data
Bioavailability  ?
Protein binding >95%
Metabolism  ?
Half life 19 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? Image File history File links Estrone. ... IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... The melting point of a crystalline solid is the temperature at which it changes state from solid to liquid. ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Many drugs are bound to Blood plasma proteins. ... Overview of the citric acid cycle The citric acid cycle, one of the central metabolic pathways in aerobic organisms. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Estrone (also oestrone) is an estrogenic hormone secreted by the ovary. Its molecular formula is C18H22O2. Estrone has a melting point of 254.5 degrees Celsius. Estrone is one of the three estrogens, which also include estriol and estradiol. Estrone is the least prevalent of the three hormones, estradiol being prevalent almost always in a female body, estriol being prevalent primarily during pregnancy. Estrone is relevant to health and disease due to its conversion to estrone sulfate, a long-lived derivative of estrone. Estrone sulfate acts as a pool of estrone which can be converted as needed to the more active estradiol. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Estriol. ... A hormone (from Greek horman - to set in motion) is a chemical messenger from one cell (or group of cells) to another. ... Human female internal reproductive anatomy Ovaries are egg-producing reproductive organs found in female organisms. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Atomic mass 12. ... General Name, Symbol, Number hydrogen, H, 1 Chemical series nonmetals Group, Period, Block 1, 1, s Appearance colorless Atomic mass 1. ... General Name, Symbol, Number oxygen, O, 8 Chemical series Nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Atomic mass 15. ... Estriol. ... Chemical structure of estriol Estriol (also oestriol) is one of the three main estrogens produced by the human body. ... Estradiol (17β-estradiol) (also oestradiol) is a sex hormone. ... Hormone is also the NATO reporting name for the Soviet/Russian Kamov Ka-25 military helicopter. ... Estradiol (17β-estradiol) (also oestradiol) is a sex hormone. ... Chemical structure of estriol Estriol (also oestriol) is one of the three main estrogens produced by the human body. ... The term trimester redirects here. ...


Synthesis

Estrone is synthesized from androstenedione, a derivative of progesterone. The conversion consists of the de-methylation of C-19 and the aromaticity of the 'A' ring. This reaction is similar to the conversion of testosterone to estradiol. Shortcut E1. Androstenedione (also known as 4-androstenedione) is a 19-carbon steroid hormone produced in the adrenal glands and the gonads as an intermediate step in the biochemical pathway that produces the androgen testosterone and the estrogens estrone and estradiol. ... Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. ... Methylation is a term used in the chemical sciences to denote the attachment or substitution of a methyl group on various substrates. ... In chemistry, an aromatic molecule is one in which electrons are free to cycle around circular arrangements of atoms, which are alternately singly and doubly bonded to one another. ... Testosterone is a steroid hormone from the androgen group. ... Estradiol (17β-estradiol) (also oestradiol) is a sex hormone. ...


Image:Reaction-Androstendione-Estrone.png Wikipedia does not have an article with this exact name. ...



Sex hormones and related medications (primarily G03, also L02, H01C) edit
Progestogens:
(receptor)

Desogestrel, Drospirenone, Dydrogesterone, Ethisterone, Etonogestrel, Ethynodiol diacetate, Gestodene, Gestonorone, Levonorgestrel, Lynestrenol, Medroxyprogesterone, Megestrol, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Progesterone, Tibolone
Antiprogestogen: Mifepristone Sex hormones are hormones that affect the reproductive system. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Progestagens (also spelled progestogens or gestagens) are hormones which produce effects similar to progesterone, the only natural progestagen. ... The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. ... A progestin is a synthetic progestagen. ... A progestin is a synthetic progestagen. ... Dydrogesterone is a progestogen hormone. ... Ethisterone is a progestogen hormone. ... Etonogestrel is a molecule used in hormonal contraceptives. ... A progestin is a synthetic progestagen. ... Gestodene is a molecule used in hormonal contraceptives. ... Gestonorone is a progestagen hormone. ... Progesterone is a steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. ... Lynestrenol is a progestagen hormone. ... Medroxyprogesterone is a molecule used in hormonal contraceptives. ... Megestrol is a molecule used in hormonal contraceptives. ... Norelgestromin is a molecule used in hormonal contraceptives. ... Norethisterone (or norethindrone) is a molecule used in hormonal contraceptives. ... Norethynodrel was the progestin used in Enovid, the first oral contraceptive. ... A progestin is a synthetic progestagen. ... A progestin is a synthetic progestagen. ... Norgestrienone is a progestogen hormone. ... Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. ... Tibolone is a synthetic hormone-type drug. ... Mifepristone is a synthetic steroid compound used as a pharmaceutical. ...

Androgens:
(receptor)

Androstanolone, Fluoxymesterone, Mesterolone, Methyltestosterone, Testosterone, (see also anabolic steroids)
Antiandrogens: Bicalutamide, Cyproterone, Flutamide, Nilutamide, Spironolactone Androgen is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors. ... The androgen receptor is an intracellular steroid receptor that specifically binds testosterone and dihydrotestosterone. ... Dihydrotestosterone (DHT) (Full name: 5α-Dihydrotestosterone, abbreviating to 5α-DHT; INN: androstanolone) is a biologically active metabolite of the hormone testosterone, formed primarily in the prostate gland, testes, hair follicles, and adrenal glands by the enzyme 5α-reductase by means of reducing the Δ4,5 double-bond. ... Fluoxymesterone is an androgen hormone. ... Mesterolone is an androgen hormone. ... Methyltestosterone is a hormone used to treat men with a testosterone deficiency. ... Testosterone is a steroid hormone from the androgen group. ... Anabolic steroids are a class of natural and synthetic steroid hormones that promote cell growth and division, resulting in growth of muscle tissue and sometimes bone size and strength. ... An antiandrogen, or androgen antagonist, is any of a group of hormone antagonist compounds that are capable of preventing or inhibiting the biologic effects of androgens, male sex hormones, on normally responsive tissues in the body (see androgen insensitivity syndrome). ... Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. ... Cyproterone acetate (Androcur®, Cyprostat®) is an antiandrogen, i. ... Flutamide is an oral antiandrogen drug primarily used to treat prostate cancer. ... Nilutamide is an antiandrogen medication used in the treatment of advanced stage prostate cancer. ... Spironolactone (marketed as Aldactone or Spiritone) is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat low-renin hypertension, hypokalemia, and Conns syndrome. ...

Estrogens:
(receptor)

Chlorotrianisene, Dienestrol, Diethylstilbestrol, Estradiol, Estriol, Estrone, Ethinylestradiol, Fosfestrol, Mestranol, Polyestradiol phosphate
Selective estrogen receptor modulator: Bazedoxifene, Clomifene, Fulvestrant, Raloxifene, Tamoxifen, Toremifene
Aromatase inhibitor: Aminogluthetimide, Anastrozole, Exemestane, Formestane, Letrozole, Vorozole Estriol. ... The estrogen receptor is a receptor for estradiol (the main endogenous estrogen); it is located intracellularly, in parallel with other steroid hormone receptors. ... Chlorotrianisene is a synthetic estrogen. ... Dienestrol is a synthetic estrogen. ... Diethylstilbestrol (DES) is a drug, a synthetic nonsteroidal estrogen that was first synthesized in 1938. ... Estradiol (17β-estradiol) (also oestradiol) is a sex hormone. ... Chemical structure of estriol Estriol (also oestriol) is one of the three main estrogens produced by the human body. ... Ethinylestradiol, also ethinyl estradiol (EE), is a synthetic derivative of estradiol. ... Fosfestrol is a estrogen used as an antineoplastic agent. ... Mestranol is the 3-methyl ether of ethinylestradiol. ... Polyestradiol phosphate is an estrogen used as an antineoplastic agent. ... Selective estrogen receptor modulators (SERMs) is a class of medication that acts on the estrogen receptor. ... Bazedoxifene is a selective estrogen receptor modulator (SERM), developed by Wyeth Pharmaceuticals. ... Clomifene (INN) or clomiphene (USAN and former BAN) is a selective estrogen receptor modulator (SERM), used mainly in female infertility due to anovulation (e. ... Fulvestrant is a drug treatment of hormone receptor positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. ... Raloxifene is an oral selective estrogen receptor modulator which is used in the prevention of osteoporosis in postmenopausal women. ... Tamoxifen is an oral selective estrogen receptor modulator which is used in breast cancer treatment, and is currently the worlds largest selling breast cancer treatment. ... Toremifene is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. ... Aromatase inhibitors (AI) are a class of drugs used in the treatment of breast cancer in post- menopausal women. ... Aminoglutethimide is a first generation aromatase inhibitor used in the treatment of breast cancer and Cushings syndrome. ... Anastrozole (Arimidex) is a drug used to treat breast cancer in post-menopausal women. ... Exemestane (Trade name: Aromasin®) is an oral steroidal aromatase inhibitor used in the treatment of hormonally-responsive breast cancer. ... Formestane is an enzyme inhibitor used as an antineoplastic agent. ... Letrozole (INN, trade name Femara®) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant treatment of hormonally-responsive breast cancer. ... Vorozole is an enzyme inhibitor used as an antineoplastic agent. ...

Gonadotropins:
(FSHR/LHCGR)

ovulation stim.: Clomifene, Urofollitropin
Antigonadotropins: Danazol, Gestrinone Gonadotropins are protein hormones secreted by gonadotrope cells of the pituitary gland of vertebrates. ... The follicle stimulating hormone receptor or FSH-receptor (FSHR) is a transmembrane receptor that interacts with the follicle stimulating hormone (FSH) and represents a G protein-coupled receptor (GPCR). ... The luteinizing hormone/choriogonadotropin receptor (LHCGR), also lutropin/choriogonadotropin receptor (LCGR) is a transmembrane receptor that interacts with both luteinizing hormone (LH) and chorionic gonadotropins (such as hCG in humans) and represents a G protein-coupled receptor (GPCR). ... Ovulation is the process in the menstrual cycle by which a mature ovarian follicle ruptures and discharges an ovum (also known as an oocyte, female gamete, or casually, an egg) that participates in reproduction. ... Clomifene (INN) or clomiphene (USAN and former BAN) is a selective estrogen receptor modulator (SERM), used mainly in female infertility due to anovulation (e. ... Urofollitropin (brand names Bravelle®, Fertinex®, Follistim®, and Gonal-F®)is a purified form of follicle-stimulating hormone (FSH). ... Danazol is a derivative of the synthetic steroid ethisterone, a modified testosterone. ... Gestrinone is a synthetic steroid hormone that acts as an anti-progestin and also has some androgenic activity. ...

GnRH:
(receptor)

Gonadotropin-releasing hormone agonist: Buserelin, Goserelin, Leuprorelin, Nafarelin, Triptorelin
Gonadotropin-releasing hormone antagonist: Histrelin, Abarelix Gonadotropin-releasing hormone 1 (GNRH1 also called LHRH) is a peptide hormone responsible for the release of FSH and LH from the anterior pituitary. ... Gonadotropin-releasing hormone receptor (GNRHR) is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. ... A gonadotropin-releasing hormone agonist (GnRH agonist) is a synthetic peptide modeled after the hypothalamic neurohormone GnRH that interacts with its receptor to elicit its biologic response, the release of the pituitary hormones FSH and LH. Agonists do not quickly dissociate from the GnRH receptor. ... Buserelin is a gonadotropin releasing hormone agonist (GnRH agonist). ... Goserelin is an injectable luteinising hormone-releasing hormone analogue (LHRHa). ... Leuprolide is a gonadotropin releasing hormone agonist (GnRH agonist). ... Nafarelin is a gonadotropin releasing hormone agonist (GnRH agonist). ... Triptorelin is a gonadotropin releasing hormone agonist (GnRH agonist). ... A gonadotropin-releasing hormone antagonist (GnRH antagonist) is a synthetic peptide that competes with the neurohormone GnRH for its receptor, thus decreasing or blocking GnRH action. ... Histrelin acetate is an injectable gonadotropin releasing hormone antagonist (GnRH antagonist). ... Abarelix also called plenaxis is a drug used to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available. ...


  Results from FactBites:
 
Estrone (224 words)
This multicenter, placebo-controlled study evaluated the lowest effective daily dose of estrone sulfate (0.3, 0.625, or 1.25 mg) combined with 1000 mg elemental calcium supplementation for preventing bone loss in the immediate supplementation for preventing bone loss in the immediate postmenopausal period.
Estrone sulfate administration (0.625 and 1.25 mg) produced significant changes in various lipid measurements at both the 6- and 12-month observation points.
Estrone sulfate 0.625 mg daily, combined with 1000 mg elemental calcium supplementation, was the minimum effective dosage to prevent loss of spinal bone mineral density in postmenopausal women over a 12-month period.
  More results at FactBites »


 

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