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Etzel was founded in Jerusalem in the year 1931 by commanders who left the Haganah following the Arab riots of 1929 in protest against the Haganah's policy of restraint vis-a-vis the Arabs.
Etzel had concluded that if, by that time, the British government had not changed its White Paper policy, it was most unlikely to change it in the future.
Etzel rejected Committee X's appeal to stand down the operation, and on 22 July 1946 the King David Hotel was blown up by explosives smuggled inside in milk cans; although Etzel had warned the management of the hotel to evacuate everyone in the building, the British authorities ordered their people to remain.
Etzel co-authored a manuscript, funded by the Joyce Foundation, examining the financial impact of long-term care on state Medicaid budgets in the Midwest.
Etzel analyzed federal, state, and county policies to determine their impact on people with HIV disease and has advocated at each level of government for sound HIV policy.
Etzel is interested in HIV policy research, in particular, examining different models of care and their impact on individuals' access to services.