Experimental pathology or investigative pathology, is the study of disease mechanisms and pathophysiology. A disease is any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. ... Pathophysiology is the study of the disturbance of normal mechanical, physical, and biochemical functions that a disease causes. ...
Definition
The American Society for Investigative Pathology defines the field as follows:
Investigative pathology is an integrative discipline that links the presentation of disease in the whole organism to its fundamental cellular and molecular mechanisms. It uses a variety of structural, functional, and genetic techniques and ultimately applies research findings to the diagnosis and treatment of diseases.[1] (http://www.asip.org).
Methods
Most of the work of investigative pathologists is carried out in the laboratory. Tissue culture, polymerase chain reaction (PCR), ELISA, western blot, southern blot, northern blot and many other biotechnological methods are required to identify differences between normal and disease states in different cell types with regards to DNA, RNA, and protein as well as determining the influence of these differences on the organism as a whole. Biochemistry laboratory at the University of Cologne. ... A tissue culture is the growth of cells (tissue) separate from the organism. ... Polymerase Chain Reaction (PCR) is a molecular biological technique for amplifying (creating multiple copies of) DNA without using a living organism, such as E. coli or yeast. ... ... Picture of a Western blot with 5 vertical lanes A Western blot is a method in molecular biology to detect a certain protein in a sample by using antibody specific to that protein. ... A Southern blot is a method in molecular biology of enhancing the result of an agarose gel electrophoresis by marking specific DNA sequences. ... The Northern Blot is a technique used in molecular biology research to study gene expression. ...
Pathology (from Greek pathos, feeling, pain, suffering; and logos, study of; see also -ology) is the study of the processes underlying disease and other forms of illness, harmful abnormality, or dysfunction.
Pathology is a large and diverse field that allows a pathologist to participate in multiple areas of the field or focus their scope to a specific area.
Pathology is often considered the most scientific branch of medicine because of the available avenues of research involving human material.
This training is designed to prepare physicians for careers in academic and private practice pathology, and consists of 48 months of training of which up to 12 months are designated as electives.
Sub-specialization, to meet increasing demands and complexity of modern pathology, is encouraged and made possible by the large faculty with diverse interests.
In addition to preparing trainees for the practice of pathology, the training of medical scientists in experimentalpathology is a central focus.
Feeds |
Contact