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Encyclopedia > Extrapyramidal system
Brain: Extrapyramidal system
Medulla spinalis. (Extrapyramidal tracts are labeled "2" in red, at left.)
NeuroNames ancil-623
MeSH Extrapyramidal+tracts
Dorlands/Elsevier s_33/12787420

In human anatomy, the extrapyramidal system is a neural network located in the brain that is part of the motor system involved in the coordination of movement. The system is called "extrapyramidal" to distinguish it from the tracts of the motor cortex that reach their targets by traveling through the "pyramids" of the medulla. The pyramidal pathways (corticospinal and some corticobulbar tracts) may directly innervate motor neurons of the spinal cord or brainstem (anterior horn cells or certain cranial nerve nuclei), whereas the extrapyramidal system centers around the modulation and regulation (indirect control) of anterior horn cells. Image File history File links This is a lossless scalable vector image. ... NeuroNames is a system of nomenclature for the brain and related structures. ... Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ... Elseviers logo. ... List of bones of the human skeleton Human anatomy is primarily the scientific study of the morphology of the adult human body. ... // Traditionally, the term neural network had been used to refer to a network or circuitry of biological neurons. ... The human brain controls the central nervous system (CNS), by way of the cranial nerves and spinal cord, the peripheral nervous system (PNS) and regulates virtually all human activity. ... Structure of a skeletal muscle Muscle is one of the four tissue types. ... The corticospinal or pyramidal tract is a massive collection of axons that travel between the cerebral cortex of the brain, and the spinal cord. ... The corticospinal or pyramidal tract is a massive collection of axons that travel between the cerebral cortex of the brain and the spinal cord. ... The corticobulbar (or corticonuclear) tract is a white matter pathway connecting the cerebral cortex to the brainstem (the term bulbar referring to the brainstem). ... The anterior horn of the spinal cord (or anterior cornu, or anterior column) is the ventral (front) grey matter section of the spinal cord. ...


Extrapyramidal tracts are chiefly found in the reticular formation of the pons and medulla, and target neurons in the spinal cord involved in reflexes, locomotion, complex movements, and postural control. These tracts are in turn modulated by various parts of the central nervous system, including the nigrostriatal pathway, the basal ganglia, the cerebellum, the vestibular nuclei, and different sensory areas of the cerebral cortex. All of these regulatory components can be considered part of the extrapyramidal system, in that they modulate motor activity without directly innervating motor neurons. The reticular formation is a part of the brain which is involved in stereotypical actions, such as walking, sleeping, and lying down. ... For other uses, see Pons (disambiguation). ... Medulla in general means the inner part, and derives from the Latin word for marrow. In medicine it is contrasted to the cortex. ... The nigrostriatal pathway is a neural pathway which connects the substantia nigra with the striatum. ... The basal ganglia (or basal nuclei) are a group of nuclei in the brain interconnected with the cerebral cortex, thalamus and brainstem. ... The cerebellum (Latin: little brain) is a region of the brain that plays an important role in the integration of sensory perception and motor output. ... The nuclei of the vestibular nerve. ... For other uses, see Cortex. ...

Contents

Extrapyramidal symptoms

The extrapyramidal system can be affected in a number of ways, which are revealed in a range of extrapyramidal symptoms such as akinesia (inability to initiate movement) and akathisia (inability to remain motionless). Akinesia is the inability to initiate movement, due to problems with selecting and activating motor programs in the brain. ... Akathisia (or acathisia) is an often extremely unpleasant subjective sensation of inner restlessness that manifests itself with an inability to sit still or remain motionless, hence the origin of its name: Greek a (without) + kathesis (sitting). ...


Extrapyramidal symptoms (EPS) are the various movement disorders such as tardive dyskinesia suffered as a result of taking dopamine antagonists, usually antipsychotic (neuroleptic) drugs, which are often used to control psychosis, especially schizophrenia. Other antidopaminergic drugs like the antiemetic metoclopramide or the tricyclic antidepressant amoxapine can also cause extrapyramidal side effects. Adverse effect, in medicine, is an abnormal, harmful, undesired and/or unintended side-effect, although not necessarily unexpected, which is obtained as the result of a therapy or other medical intervention, such as drug/chemotherapy, physical therapy, surgery, medical procedure, use of a medical device, etc. ... List of Movement disorders Akinesia (lack of movement) Athetosis (contorted torsion or twisting) Ataxia Ballismus (violent involuntary rapid and irregular movements) Hemiballismus Bradykinesia (slow movement) Chorea (rapid, involuntary movement) Sydenhams chorea Rheumatic chorea Huntingtons chorea Dystonia (sustained torsion) Dystonia muscularum Blepharospasm Writers cramp Spasmodic torticollis (twisting of... Tardive dyskinesia is a serious neurological disorder caused by the long-term and/or high-dose use of dopamine antagonists, usually antipsychotics and among them especially the typical antipsychotics. ... A dopamine antagonist is a drug which blocks dopamine receptors (of which there are five types in the human body; they are found in the brain, peripheral nervous system, blood vessels, and the kidney). ... The term antipsychotic is applied to a group of drugs used to treat psychosis. ... This article does not cite any references or sources. ... For other uses, see Psychosis (disambiguation). ... This page is a candidate to be moved to Wiktionary. ... An antiemetic is a drug that is effective against vomiting and nausea. ... Metoclopramide (INN) (IPA: ) is a potent dopamine receptor antagonist used for its antiemetic and prokinetic properties. ... Chemical structure of the tricyclic antidepressant amitriptyline. ... Amoxapine (Asendin®; Asendis®; Defanyl®; Demolox®; Moxadil®) is a tricyclic antidepressant of the dibenzoxazepine class. ...


Disorders

The best known EPS is tardive dyskinesia (involuntary, irregular muscle movements, usually in the face). Other common EPS include akathisia (restlessness), dystonia (muscular spasms of neck - torticollis, eyes - oculogyric crisis, tongue, or jaw; more frequent in children), drug-induced parkinsonism (musclar lead-pipe rigidity, bradykinesia/akinesia, resting tremor, postural instability; more frequent in adults and the elderly), Tardive dyskinesia is a serious neurological disorder caused by the long-term and/or high-dose use of dopamine antagonists, usually antipsychotics and among them especially the typical antipsychotics. ... Akathisia (or acathisia) is an often extremely unpleasant subjective sensation of inner restlessness that manifests itself with an inability to sit still or remain motionless, hence the origin of its name: Greek a (without) + kathesis (sitting). ... Dystonia is a neurological movement disorder in which sustained muscle contractions cause twisting and repetitive movements or abnormal postures. ... Torticollis, or wry neck, is a condition in which the head is tilted toward one side, and the chin is elevated and turned toward the opposite side. ... Oculogyric crisis (OGC) is the name of a severe reaction to certain drugs and/or medical conditions including neuroleptics, amantadine, benzodiazepines, carbamazepine, chloroquine, cisplatin, diazoxide, influenza vaccine, levodopa, lithium, metoclopramide, nifedipine, pemoline, phencyclidine, reserpine, tricyclics, postencephalitic Parkinsons, Tourettes syndrome, multiple sclerosis, neurosyphilis, head trauma, bilateral thalamic infarction, lesions... Parkinsonism (also known as Parkinsons syndrome, atypical Parkinsons, or secondary Parkinsons) is a neurological syndrome characterized by tremor, hypokinesia, rigidity, and postural instability. ...


Although Parkinson's Disease is primarily a disease of the nigrostriatal pathway and not the extrapyramidal system, loss of dopaminergic neurons in the substantia nigra leads to dysregulation of the extrapyramidal system. Since this system regulates posture and skeletal muscle tone, a result is the characteristic bradykinesia of Parkinson's. The nigrostriatal pathway is a neural pathway which connects the substantia nigra with the striatum. ... The substantia nigra, (Latin for black substance, Soemering) or locus niger is a heterogeneous portion of the midbrain, separating the pes (foot) from the tegmentum (covering), and a major element of the basal ganglia system. ... In medicine (neurology), bradykinesia denotes slow movement (etymology: brady = slow, kinesia = movement). ...


Extrapyramidal symptoms can also be caused by brain damage, as in athetotic cerebral palsy, which is involuntary writhing movements caused by prenatal or perinatal brain damage. Cerebral palsy (CP) is an umbrella term encompassing a group of non-progressive,[1] non-contagious diseases that cause physical disability in human development. ...


Treatment for extrapyramidal symptoms

Anticholinergic drugs are used to control neuroleptic-induced EPS, although akathisia may require beta blockers or even benzodiazepines. If the EPS are induced by a typical antipsychotic, EPS may be reduced by dose titration or by switching to an atypical antipsychotic, such as aripiprazole, ziprasidone, quetiapine, olanzapine, risperidone or clozapine. These medications possess an additional mode of action that is believed to negate their effect on the nigrostriatal pathway, which means they are associated with fewer extrapyramidal side effects than "conventional" antipsychotics (chlorpromazine, haloperidol, etc.). An anticholinergic agent is a member of a class of pharmaceutical compounds which serve to reduce the effects mediated by acetylcholine in the central nervous system and peripheral nervous system. ... The term antipsychotic is applied to a group of drugs used to treat psychosis. ... Akathisia (or acathisia) is an often extremely unpleasant subjective sensation of inner restlessness that manifests itself with an inability to sit still or remain motionless, hence the origin of its name: Greek a (without) + kathesis (sitting). ... Beta blockers or beta-adrenergic blocking agents are a class of drugs used to treat a variety of cardiovascular conditions and some other diseases. ... Alprazolam 2 mg tablets The benzodiazepines (pronounced , or benzos for short) are a class of psychoactive drugs considered minor tranquilizers with varying hypnotic, sedative, anxiolytic, anticonvulsant, muscle relaxant and amnesic properties, which are mediated by slowing down the central nervous system. ... Typical antipsychotics (sometimes referred to as conventional antipsychotics or conventional neuroleptics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia), and are generally being replaced by atypical antipsychotic drugs. ... The atypical antipsychotics (also known as second generation antipsychotics) are a class of prescription medications used to treat psychiatric conditions. ... Aripiprazole (produced by Otsuka Pharmaceutical Co,. Ltd. ... Ziprasidone (marketed as Geodon, Zeldox) was the fifth atypical antipsychotic to gain FDA approval (February 2001). ... Quetiapine (IPA: , kwe-TYE-a-peen), marketed by AstraZeneca with the brand name Seroquel, belongs to a series of neuroleptics known as atypical antipsychotics, which have, over the last two decades, become increasingly popular alternatives to typical antipsychotics, such as haloperidol. ... Olanzapine (oh-LAN-za-peen, sold as Zyprexa®, Zyprexa Zydis®, or in combination with fluoxetine, as Symbyax®) was the third atypical antipsychotic to gain approval by the Food and Drug Administration (FDA) and has become one of the most commonly used atypical antipsychotics. ... Risperdal tablets Risperidone (pronounced Ris-PER-ǐ-dōn and sold under the trade name Risperdal in the United States, Canada, the United Kingdom, Portugal and several other countries, Risperdal or Ridal in New Zealand, Rispolept in Eastern Europe, and Belivon, or Rispen elsewhere) is an atypical antipsychotic medication developed by... Clozapine (sold as Clozaril®, Leponex®, Fazaclo®) was the first of the atypical antipsychotics to be developed. ... Chlorpromazine was the first antipsychotic drug, used during the 1950s and 1960s. ... Haloperidol (sold under the tradenames Aloperidin, Bioperidolo, Brotopon, Dozic, Duraperidol (Germany), Einalon S, Eukystol, Haldol, Halosten, Keselan, Linton, Peluces, Serenace, Serenase, Sigaperidol) is a conventional, or typical, butyrophenone antipsychotic drug. ...


Commonly used medications for EPS are benztropine (Cogentin), diphenhydramine (Benadryl), and trihexyphenidyl (Artane).exp Benztropine (Cogentin®) is an anticholinergic drug principally used for the treatment of: Drug-induced parkinsonism, akathisia and acute dystonia; Parkinson disease; and Idiopathic or secondary dystonia. ... Diphenhydramine hydrochloride (trade name Benadryl, as produced by J&J, or Dimedrol outside the U.S. & Canada. ... // Introduction Trihexyphenidyl is an antiparkinson agent of the antimuscarinic class of agents and is chemically a tertiary amine. ...


See also

List of regions in the human brain // medulla oblongata medullary pyramids pons paramedian pontine reticular formation fourth ventricle cerebellum cerebellar vermis cerebellar hemispheres anterior lobe posterior lobe flocculonodular lobe cerebellar nuclei fastigial nucleus globose nucleus emboliform nucleus dentate nucleus tectum inferior colliculi superior colliculi mesencephalic duct (cerebral aqueduct, Aqueduct of Sylvius) cerebral peduncle midbrain tegmentum ventral tegmental...


  Results from FactBites:
 
Motor Systems (1173 words)
The pyramidal system is a two neuron system consisting of upper motor neurons in the Primary Motor Cortex and lower motor neurons in the anterior horn of the spinal cord.
The main sensory organ of the vestibular system is located in the inner ear and consists of the Utricle, the Sacculus and the Semicircular canals.
The major cerebellar tracts are the Spinocerebellar, connecting the spinal cord and the cerebellum, the Vestibulospinal, connecting the vestibular system and the cerebellum, Corticopontocerebellar, connecting the cortex, pons and cerebellum and the Dentatorubrothalamic connecting the dentate nucleus of the cerebellum, the red nucleus and the thalamus.
Extrapyramidal system - Wikipedia, the free encyclopedia (347 words)
In human anatomy, the extrapyramidal system is a neural network located in the brain that is part of the motor system involved in the coordination of movement.
The extrapyramidal system can be affected in a number of ways, which are revealed in a range of extrapyramidal symptoms such as akinesia and akathisia.
Extrapyramidal side effects (EPS) are the various movement disorders suffered as a result of taking dopamine antagonists, usually antipsychotic (neuroleptic) drugs, which are often used to control psychosis, especially schizophrenia.
  More results at FactBites »


 
 

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