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Her husband Philip was the Habsburg son of the Holy Roman Emperor Maximilian I and Mary of Burgundy and simultaneously became king-consort Philip I of Castile.
Ferdinand's first investment of Spanish forces came in the War of the League of Cambrai against Venice, where the Spanish soldiers distinguished themselves on the field alongside their French allies at the Battle of Agnadello (1509).
Ferdinand's death led to the ascension of young Charles to the throne as Charles I of Castile and Aragon, effectively founding the monarchy of Spain.
Ferdinand was born in Madrid, the son of Juana the Mad, Queen of Castile (1479–1555), and Philip I the Handsome, King of Castile (1478–1506), who was heir to Holy Roman Emperor Maximilian I of Habsburg.
Ferdinand was the younger brother of Holy Roman Emperor Charles V, who entrusted him with the government of the Habsburg hereditary lands (roughly modern-day Austria and Slovenia).