Fibroadenoma of the breast is a benign tumor characterized by proliferation of both glandular and stromal elements. Tumor (American English) or tumour (British English) originally means swelling, and is sometimes still used with that meaning. ...
Most often it appears before age 30 as a result of estrogenic hormonal excess. Usually the tumor is solitary, multiple tumors being rare. The tumor is mobile to adjacent structures: skin, muscle, lymph nodes. Estrogens (also oestrogens) are a group of steroid compounds, named for their importance in the oestrus cycle, functioning as the primary female sex hormone. ...
Pathology
Macroscopically: The tumor is round, elastic, nodular, and encapsulated (well circumscribed); on cut surface it is grey-white. Microscopically: The epithelial proliferation describes duct-like spaces surrounded by a fibroblastic stroma. The proliferated epithelium is typical. Depending on the amount and the relationship between these two components, there are two main histological features: intracanalicular and pericanalicular. Often, both types are found in the same tumor. Intracanalicular fibroadenoma: stromal proliferation predominates and compresses the ducts, which are irregular, reduced to slits. Pericanalicular fibroadenoma: fibrous stroma proliferates around the ductal spaces, so that they remain round or oval, on cross section. The basement membrane is intact. 1
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