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Encyclopedia > Fibroblasts

A fibroblast is a cell that makes the structural fibers and ground substance of connective tissue. It has a branched cytoplasm surrounding an elliptical, speckled nucleus having 1 or 2 nucleoli. Active fibroblasts can be recognized by their abundant rough endoplasmic reticulum. Inactive fibroblasts, which are also called fibrocytes, are smaller and spindle shaped. They have a reduced rough endoplasmic reticulum.


Fibroblasts make collagens, glycosaminoglycans, reticular and elastic fibers, and glycoproteins found in the extracellular matrix. In growing individuals fibroblasts are dividing and synthesizing ground substance. Tissue damage stimulates fibrocytes and induces the mitosis of fibroblasts.


Fibroblasts can give rise to other cells, such as bone cells, fat cells, and smooth muscle cells. Note that all of these cells are of mesodermal origin.


See also: fibrocartilage callus


  Results from FactBites:
 
BioMed Central | Full text | Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo (4585 words)
Fibroblasts were isolated from the dermis of late gestation embryos in mice deficient in MT1-MMP[8], MMP-2 [9] and MMP-9 [10].
Fibroblasts were used between passages 2–6 and maintained in DMEM supplemented with 10% (v/v) fetal bovine serum (Mediatech, Herdon, VA) and antibiotics (100 units/ml penicillin and 100 ug/ml streptomycin sulphate, Mediatech).
To compensate for the potential negative impact of this growth rate both a 1:2 ratio and a 1:3 ratio of tumor cells to fibroblasts was used for each fibroblast type to compensate for variations in primary culture growth rate [12].
Fibroblast growth factor receptors from liver vary in three structural domains -- Hou et al. 251 (4994): 665 -- Science (1114 words)
Fibroblast growth factor receptors from liver vary in three structural domains -- Hou et al.
Changes in heparin-binding fibroblast growth factor gene expression and receptor phenotype occur during liver regeneration and in hepatoma cells.
Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12).
  More results at FactBites »


 

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