In eukaryotic genetics, the five prime untranslated region (5' UTR) is a particular section of messenger RNA (mRNA). It precedes the translation initiation site of the gene, bounded on the 5' end by the start of transcription and on the 3' end by the start codon (see Figure 1 for a schematic view). In some viruses it may have additional role in enhancing the expression level or increasing the stability of RNA. It is also reported that CpG islands in the 5' UTR are important for regulation as they are sites of methylation. One research paper also reports that "CpG islands in mammalian gene promoters are inherently resistant to de novo methylation". Kingdoms Eukaryotes are organisms with complex cells, in which the genetic material is organized into membrane-bound nuclei. ... Genetics (from the Greek genno γεννώ= give birth) is the science of genes, heredity, and the variation of organisms. ... The interaction of mRNA in a eukaryote cell. ... Translation is the second process of protein biosynthesis (part of the overall process of gene expression). ... This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ... Transcription is the process through which a DNA sequence is enzymatically copied by an RNA polymerase to produce a complementary RNA. Or, in other words, the transfer of genetic information from DNA into RNA. In the case of protein-encoding DNA, transcription is the beginning of the process that ultimately... The human immunodeficiency virus (HIV) A bacteriophage virus A virus is a submicroscopic parasitic particle that infects cells in biological organisms. ...

Figure 1. Schematic of Central Dogma of Biology in eukaryotes illustrating the definition of the 5'UTR

Image File history File links 5primeUTR_PictorialDefinition. ... Image File history File links 5primeUTR_PictorialDefinition. ...

General reference

• "Eukaryotic Primary RNA Transcripts Are Processed to Form Functional mRNAs" in Molecular Cell Biology, 4th ed., Lodish, Harvey, et al. Online version in the NCBI Bookshelf.
• CpG islands in mammalian gene promoters are inherently resistant to de novo methylation Pubmed entry