Fludrocortisone acetate is a synthetic corticosteroid with moderate glucocorticoid potency and much greater mineralocorticoid potency. It is used primarily to replace mineralocorticoids in various forms of adrenal insufficiency such as Addison's disease and congenital adrenal hyperplasia. It is occasionally used to treat orthostatic hypotension as well.

The brand name in the U.S. is Florinef. It is available in 0.1 mg tablets. Typical daily doses for mineralocorticoid replacement are 1/2 to 2 tablets a day. In this dose glucocorticoid effect is minimal.