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Encyclopedia > Flumazenil
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Flumazenil chemical structure
Flumazenil Flumazenil structure. ...

ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-
4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
CAS number
78755-81-4
ATC code
V03AB25
Chemical formula C15H14FN3O3
Molecular weight 303.29
Metabolism Hepatic
Elimination half life 7-15 min (initial)
20-30 min (brain)
40-80 min (terminal)
Excretion Urine 90-95%
Feces 5-10%
Pregnancy category C
Legal status  ?
Delivery Intravenous

Flumazenil (flumazepil, Anexate®, Lanexat®, Mazicon®, Romazicon®) is a benzodiazepine antagonist, used as an antidote in the treatment of benzodiazepine overdose. It reverses the effects of benzodiazepines by competitive inhibition of benzodiazepine receptors. CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... Jump to: navigation, search Half-Life is a science fiction first-person shooter computer game developed by Valve Software and published by Sierra Entertainment in 1998, based on a heavily-modified Quake game engine. ... Jump to: navigation, search Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ... The Controlled Substances Act (CSA), Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970, is the legal foundation of the United States governments fight against the abuse of drugs and other substances. ... Image:Benzodiazepine. ... Categories: Biology stubs | Biochemistry | Pharmacology ... An antidote is a substance which can counteract a form of poisoning. ... A drug overdose occurs when a chemical substance (i. ... In biochemistry one distinguishes two ways in which a molecule may block the action of an enzymes: competitive and noncompetitive inhibition. ... In biochemistry, a receptor is a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific factor (a ligand), such as a neurotransmitter, hormone, or other substance, and initiates the cellular response to the ligand. ...


The onset of action is very fast, about one to two minutes. The activity peak is six to ten minutes. Many benzodiazepines have longer half-lives than flumazenil. Therefore repeat doses of flumazenil may be required to prevent recurrent symptoms of overdosage once the initial dose of flumazenil wears off. Half-Life For a quantity subject to exponential decay, the half-life is the time required for the quantity to fall to half of its initial value. ... The term symptom (from the Greek syn = con/plus and pipto = fall, together meaning co-exist) has two similar meanings in the context of physical and mental health: A symptom may loosely be said to be a physical condition which shows that one has a particular illness or disorder (see...


It was introduced in 1987 by Hoffmann-La Roche under trade name Anexate. Jump to: navigation, search Hoffmann-La Roche, Ltd. ...


  Results from FactBites:
 
Romazicon (Flumazenil) drug warnings and precautions - prescription drugs and medications at RxList (2526 words)
The administration of flumazenil can precipitate benzodiazepine withdrawal in animals and man. This has been seen in healthy volunteers treated with therapeutic doses of oral lorazepam for up to 2 weeks who exhibited effects such as hot flushes, agitation and tremor when treated with cumulative doses of up to 3 mg doses of flumazenil.
Flumazenil caused a slight increase in unscheduled DNA synthesis in rat hepatocyte culture at concentrations which were also cytotoxic; no increase in DNA repair was observed in male mouse germ cells in an in vivo DNA repair assay.
Pup survival was decreased during the lactating period, pup liver weight at weaning was increased for the high-dose group (125 mg/kg/day) and incisor eruption and ear opening in the offspring were delayed; the delay in ear opening was associated with a delay in the appearance of the auditory startle response.
Flumanazil | Poison Control Center - Children's Hospital of Philadelphia (1412 words)
The pharmacologic profile of flumazenil is unaltered in the presence of benzodiazepine agonists and the kinetics profiles of those benzodiazepines are unaltered by flumazenil.
Flumazenil may be considered for the reversal of benzodiazepine sedation in cases where general anesthesia has been induced and/or maintained with benzodiazepines; where sedation has been produced by benzodiazepines for diagnostic and therapeutic procedures; in therapeutic misadventures and for the management of benzodiazepine overdose in patients who are not at risk for seizures.
Flumazenil is a benzodiazepine antagonist with clinical utility in the reversal of sedation and CNS depression due to benzodiazepines.
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