Quinolones and fluoroquinolones form a group of broad-spectrum antibiotics.
Fluoroquinolone antibiotics are highly potent and considered relatively safe. However, they can have potentially troublesome side effects. For example, case reports have implicated their use in rare instances of tendon damage, especially when administered with a systemic corticosteroid.
Mechanism
Quinolones act by inhibiting the bacterial DNA gyrase enzyme.
Fluoroquinolones are bactericidal agents that exhibit concentration-dependent killing against a broad spectrum of pathogens.
Although seizures are infrequent, fluoroquinolones should be avoided in patients with a history of convulsion, cerebral trauma, or anoxia.
A recent study found that the use of fluoroquinolones was associated with tendon or join disorders in <1% of children—similar to the incidence with the comparator azithromycin.
Feeds |
Contact