Follistatin
The Structure Of The Follistatin:Activin Complex
Other names:	FS, Activin-binding protein
Genetic data
Gene code:	HUGO code:FST
Protein Structure/Function
Structure:	Follistatin:Activin Complex structure
Protein type:	Growth factor
Functions:	Regulates members of the TGF beta superfamily ligands
Domains:	3 FOLN domains, 3 KAZAL domains
Other
Taxa expressing:	Homo Sapiens; homologs: many metazoan phyla
Cell types:	many, placenta, blood, ovary, liver, testis
Subcellular localization:	extracellular
Molecular interactions:	Activin, inhibin, BMP5
Medical/Biotechnological data
Diseases:	polycystic ovary syndrome (PCOS)

Follistatin is a single chain gonadal protein that inhibits Follicle-stimulating hormone release. It binds to and antagonizes Activin, which enhances FSH secretion. There are three known isoforms created by alternative splicing. Genetics (from the Greek genno γεννώ= give birth) is the science of genes, heredity, and the variation of organisms. ... Hugo is a masculine name. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... Growth factor is a protein that acts as a signaling molecule between cells (like cytokines and hormones) that attaches to specific receptors on the surface of a target cell and promotes differentiation and maturation of these cells. ... Within a protein, a structural domain (domain) is an element of overall structure that is self-stabilizing and often folds independently of the rest of the protein chain. ... A taxon (plural taxa), or taxonomic unit, is a grouping of organisms (named or unnamed). ... Human beings are defined variously in biological, spiritual, and cultural terms, or in combinations thereof. ... Phyla Subkingdom Parazoa Porifera (sponges) Subkingdom Agnotozoa Placozoa Orthonectida Rhombozoa Subkingdom Metazoa Radiata Cnidaria Ctenophora - Comb jellies Bilateria Protostomia Acoelomorpha Platyhelminthes - Flatworms Nemertina - Ribbon worms Gastrotricha Gnathostomulida - Jawed worms Micrognathozoa Rotifera - Rotifers Acanthocephala Priapulida Kinorhyncha Loricifera Entoprocta Nematoda - Roundworms Nematomorpha - Horsehair worms Cycliophora Mollusca - Mollusks Sipuncula - Peanut worms Annelida - Segmented... Phylum (plural: phyla) is a taxon used in the classification of animals, adopted from the Greek phylai the clan-based voting groups in Greek city-states. ... There are about 210 types of human cells. ... The placenta is an ephemeral (temporary) organ present only in female placental vertebrates during gestation (pregnancy). ... Human blood smear: a - erythrocytes; b - neutrophil; c - eosinophil; d - lymphocyte. ... Human female internal reproductive anatomy Ovaries are egg-producing reproductive organs found in female organisms. ... The liver is an organ in some animals, including mammals (and therefore humans), birds, and reptiles. ... Human male anatomy The testicles, known medically as testes (singular testis), are the male generative glands in animals. ... In cell biology, molecular biology and related fields, the word extracellular means outside the cell. It is used in contrast to intracellular (inside the cell). ... In chemistry, a molecule is an aggregate of two or more atoms in a definite arrangement held together by chemical bonds [1] [2] [3] [4] [5]. Chemical substances are not infinitely divisible into smaller fractions of the same substance: a molecule is generally considered the smallest particle of a pure... Activin is a peptide that enhances FSH synthesis and secretion and participates in the regulation of the menstrual cycle. ... Inhibin is a peptide that is an inhibitor of FSH synthesis and secretion and participates in the regulation of the menstrual cycle. ... Bone morphogenetic protein 5 (BMP5) is a polypeptide member of the TGFβ superfamily of proteins. ... A disease or medical condition is an abnormality of the body or mind that causes discomfort, dysfunction, distress, or death to the person afflicted or those in contact with the person. ... Polycystic ovary syndrome (PCOS, also known clinically as Stein-Leventhal syndrome), is an endocrine disorder that affects 5–10% of women. ... The gonad is the organ that makes gametes. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... Follicle stimulating hormone Follicle stimulating hormone (FSH) is a hormone synthesised and secreted by gonadotropes in the anterior pituitary gland. ... Antagonists In medicine and biology, a receptor antagonist is a ligand that inhibits the function of an agonist and inverse agonist for a specific receptor. ... Activin is a peptide that enhances FSH synthesis and secretion and participates in the regulation of the menstrual cycle. ... Various modes of alternative splicing Alternative splicing is the process that occurs in eukaryotes in which the splicing process of a pre-mRNA transcribed from one gene can lead to different mature mRNA molecules and therefore to different proteins. ...

Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 5 is one of the 23 pairs of chromosomes in humans. ...