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Encyclopedia > Fondaparinux
Fondaparinux
Systematic (IUPAC) name
methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl-(1→

4)-O-ß-D-glucopyranuronosyl-(1→4)-O-2-deoxy-3,6-di-O-sulfo-2- (sulfoamino)-α-D-glucopyranosyl-(1→4)-O-2-O-sulfo-α-L-idopyranuronosyl-(1→ 4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranoside, decasodium salt. Image File history File links Download high-resolution version (2270x500, 423 KB) I, the creator of this work, hereby release it into the public domain. ... IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ...

Identifiers
CAS number 114870-03-0
ATC code B01AX05
PubChem 636380
DrugBank APRD00500
Chemical data
Formula C31H43N3Na10O49S8 
Mol. mass 1726.77 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 94%
Metabolism  ?
Half life 17-21 hours
Excretion  ?
Therapeutic considerations
Licence data

EU US CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules. ... The DrugBank database available at the University of Alberta is a unique bioinformatics and cheminformatics resource that combines detailed drug (i. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... General Name, Symbol, Number carbon, C, 6 Chemical series nonmetals Group, Period, Block 14, 2, p Appearance black (graphite) colorless (diamond) Atomic mass 12. ... This article is about the chemistry of hydrogen. ... General Name, Symbol, Number nitrogen, N, 7 Chemical series nonmetals Group, Period, Block 15, 2, p Appearance colorless gas Atomic mass 14. ... General Name, Symbol, Number sodium, Na, 11 Chemical series alkali metals Group, Period, Block 1, 3, s Appearance silvery white Atomic mass 22. ... General Name, Symbol, Number oxygen, O, 8 Chemical series Nonmetals, chalcogens Group, Period, Block 16, 2, p Appearance colorless (gas) very pale blue (liquid) Atomic mass 15. ... General Name, Symbol, Number sulfur, S, 16 Chemical series nonmetals Group, Period, Block 16, 3, p Appearance lemon yellow Atomic mass 32. ... The molecular mass (abbreviated MM) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Many drugs are bound to Blood plasma proteins. ... Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ... It has been suggested that Effective half-life be merged into this article or section. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ...

Pregnancy cat.

? The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Fondaparinux (Arixtra) is an anticoagulant medication. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... An anticoagulant is a substance that prevents coagulation; that is, it stops blood from clotting. ...


As shown in the box to the right, Fondaparinux contains a synthetic pentasaccharide. Apart from the O-methyl group at the reducing end of the molecule, the identity and sequence of the five monomeric sugar units contained in Fondaparinux is identical to a sequence of five monomeric sugar units that can be isolated after either chemical or enzymatic cleavage of the polymeric glycosaminoglycans heparin and heparan sulfate (HS). Within heparin and heparan sulfate this monomeric sequence is thought to form the high affinity binding site for the anti-coagulant factor antithrombin III (ATIII). Binding of heparin/HS to ATIII has been shown to increase the anti-coagulant activity of antithrombin III 1000 fold. See the heparin article for a detailed rationale behind the development of Fondaparinux as an anticoagulant. Glycosaminoglycans (GAGs) are long unbranched polysaccharides, made up of repeating disaccharides that may be sulphated (e. ... Heparin is a highly sulfated glycosaminoglycan widely used as an injectable anticoagulant. ... Heparan Sulfate (HS) is a linear polysaccharide found in all animal tissues. ... Antithrombin is a small molecule that inactivates several enzymes of the coagulation system. ... Heparin is a highly sulfated glycosaminoglycan widely used as an injectable anticoagulant. ...


Fondaparinux is given subcutaneously daily. Clinically, it is used for the prevention of deep vein thrombosis in patients who have had orthopedic surgery as well as for the treatment of deep vein thrombosis and pulmonary embolism. Deep-vein thrombosis, also known as deep-venous thrombosis or DVT, is the formation of a blood clot (thrombus) in a deep vein. ...


One potential advantage of fondaparinux over LMWH or unfractionated heparin is that the risk for heparin-induced thrombocytopenia is substantially lower. Furthermore, there have been case reports of fondaparinux being used to anticoagulate patients with established HIT as it has no affinity to PF-4. However, its renal excretion precludes its use in patients with renal dysfunction. Heparin-induced thrombocytopenia (HIT) with or without thrombosis (HITT) is thrombocytopenia (low platelet counts) due to the administration of heparin. ...

Contents

Randomized Controlled Trials

Fondaparinux is similar to enoxaparin in reducing the risk of ischemic events at nine days, but it substantially reduces major bleeding and improves long term mortality and morbidity.[1] Enoxaparin is a low molecular weight heparin manufactured by Sanofi-Aventis. ...


Chemical structure

Abbreviations

  • GlcNS(6S) = 2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranoside
  • GlcA = ß-D-glucopyranuronosyl
  • GlcNS(3S,6S) = 2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-α-D-glucopyranosyl
  • IdoA(2S) = 2-O-sulfo-α-L-idopyranuronosyl
  • GlcNS(6S)OMe = methyl-O-2-deoxy-6-O-sulfo-2-(sulfoamino)-α-D-glucopyranoside

The α-D form of glucuronic acid. ... The introduction to this article provides insufficient context for those unfamiliar with the subject matter. ... Image File history File links Download high-resolution version (897x262, 43 KB) I, the creator of this work, hereby release it into the public domain. ...


External links

v • d • e
Antithrombotics (thrombolytics, anticoagulants, and antiplatelet drugs) (B01)
Vitamin K antagonists Acenocoumarol, Clorindione, Dicumarol (Dicoumarol), Diphenadione, Ethyl biscoumacetate, Phenprocoumon, Phenindione, Tioclomarol, Warfarin
Heparin group
(Platelet aggregation inhibitors)		 Antithrombin III, Bemiparin, Dalteparin, Danaparoid, Enoxaparin, Heparin, Nadroparin, Parnaparin, Reviparin, Sulodexide, Tinzaparin
Other platelet
aggregation inhibitors		 Abciximab, Acetylsalicylic acid (Aspirin), Aloxiprin, Beraprost, Ditazole, Carbasalate calcium, Cloricromen, Clopidogrel, Dipyridamole,Eptifibatide, Indobufen, Iloprost, Picotamide, Prasugrel,Prostacyclin, Ticlopidine, Tirofiban, Treprostinil, Triflusal
Enzymes Alteplase, Ancrod, Anistreplase, Brinase, Drotrecogin alfa, Fibrinolysin, Protein C, Reteplase, Saruplase, Streptokinase, Tenecteplase, Urokinase
Direct thrombin inhibitors Argatroban, Bivalirudin,Dabigatran, Desirudin, Hirudin, Lepirudin, Melagatran, Ximelagatran
Other antithrombotics Dabigatran, Defibrotide, Dermatan sulfate, Fondaparinux, Rivaroxaban
Non-medicinal Citrate, EDTA, Oxalate

  Results from FactBites:
 
fondaparinux (injectable) - [Medication] (1565 words)
Fondaparinux is in the FDA pregnancy category B. This means that it is not likely to be harmful to an unborn baby.
Fondaparinux is administered as a subcutaneous (under the skin) injection.
Fondaparinux should not be administered intramuscularly (into a muscle) or intravenously (into a vein).
Fondaparinux advanced consumer information | Drugs.com (1460 words)
Fondaparinux ((fon-da-PA-rin-ux)) is used to prevent deep vein thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs.
Fondaparinux is also used to treat deep vein thrombosis and a condition called pulmonary embolism together with warfarin (e.g., Coumadin).
Also, tell your doctor if you have received fondaparinux or heparin before and had a reaction to either of them called thrombocytopenia (a low platelet count in the blood), or if new blood clots formed while you were receiving the medicine.
  More results at FactBites »


 
 

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