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Commonly it's taught that the Fool is the protagonist of a story and the Major Arcana is the path the Fool takes through the great mysteries of life and the main human archetypes.
The conventional explanations say that the Fool signifies the flesh, the sensitive life, and by a peculiar satire its subsidiary name was at one time the alchemist, as depicting folly at the most insensate stage.
When The Fool appears in a spread, he would be a signal to strip down to the irreducible core, and interrogate whether The Querant’s self vision is obscured.