St. Vincent and the Grenadines maintains close ties to the U.S., Canada, and the United Kingdom, and cooperates with regional political and economic organizations such as the Organization of Eastern Caribbean States (OECS) and CARICOM. St. Vincent and the Grenadines is a member of the United Nations, the Commonwealth of Nations, the Organization of American States, and the Association of Caribbean States (ACS).

As a member of CARICOM, St. Vincent and the Grenadines strongly backed efforts by the United States to implement UN Security Council Resolution 940, designed to facilitate the departure of Haiti's de facto authorities from power. The country agreed to contribute personnel to the multinational force, which restored the democratically elected government of Haiti in October 1994.

In May 1997, Prime Minister Mitchell joined 14 other Caribbean leaders and U.S. President Bill Clinton during the first-ever U.S.-regional summit in Bridgetown, Barbados. The summit strengthened the basis for regional cooperation on justice and counternarcotics issues, finance and development, and trade.

St. Vincent and the Grenadines maintains close relations with Cuba, which provides a number of scholarship and other exchange programs for Vincentians, particularly in the field of healthcare. It also has diplomatic relations with the Republic of China (Taiwan) instead of the People's Republic of China.

Saint Vincent protests Venezuela's claim to give full effect to Aves Island, which creates a Venezuelan EEZ/continental shelf extending over a large portion of the Caribbean Sea

Saint Vincent is a transshipment point for South American illicit drugs destined for the US and Europe.