The Baxter Building was replaced by FourFreedomsPlaza, built at the same location, after the Baxter Building's destruction at the hands of Kristoff Vernard, adopted son of the Fantastic Four's seminal villain (and rumored half-brother of Mr.
Pier 4, a warehouse on the New York waterfront, served as a temporary headquarters for the group after FourFreedomsPlaza was condemned, due to the actions of another superhero team, the Thunderbolts.
Three of the four members are directly related (with the Thing being the exception as a beloved Dutch uncle), and additionally, the children of Mister Fantastic and the Invisible Woman, Franklin Richards and Valeria Richards, are regulars in the series.