Hofheinz began his business career with his late father, RoyHofheinz, Sr., the founder of the Houston Astrodome and the initial owner of the Houston Astros baseball team.
Hofheinz co-founded a closed circuit television company, Top Rank, which is now the leading professional boxing promotion firm in the nation.
Hofheinz also owned several direct interests in oil and gas producing properties and co-founded and served as the Chief Executive Officer of several oil and gas companies.
Roy Mark Hofheinz (April 10, 1912–November 22, 1982), popularly known as Judge Hofheinz, was mayor of the city of Houston, Texas from 1953 to 1955.
Because Hofheinz was the first baseball team owner to put his team in a domed stadium and the first to use artificial turf, it has been suggested that "the baseball gods" placed a curse on the team.
Hofheinz's son, FredHofheinz, served as mayor of Houston in the 1970s.