A fusion gene is a hybrid gene formed from two previously separate genes. It can occur as the result of a translocation, interstitial deletion, or chromosomal inversion. Often, fusion genes are oncogenes; examples include BCR-ABL, FIG-ROS, and TEL-JAK2. Chromosomal translocation of the 4th and 20th chromosome. ... An inversion is a chromosome rearrangement in which a segment of a chromosome is reversed end to end. ... An oncogene is a modified gene that increases the malignancy of a tumor cell. ... Philadelphia chromosome or Philadelphia translocation is a specific genetic, chromosomal abnormality that is associated with chronic myelogenous leukemia (CML) and involves an exchange of material between chromosomes 9 and 22. ... TEL-JAK2 is a gene fusion resulting from a chromosomal translocation between chromosomes 9 and 12 observed in human leukemia [1] [2]. The 5 moiety of TEL is fused to the 3 end of JAK2. ...
Biologists may also deliberately create fusion genes for research purposes. For example, by creating a fusion gene of a protein of interest and green fluorescent protein, the protein of interest may be observed in cells or tissue using fluorescence microscopy. The protein synthesized when a fusion gene is expressed is called a fusion protein. GFP ribbon diagram from PDB database The green fluorescent protein (GFP) is a protein from the jellyfish Aequorea victoria that fluoresces green when exposed to blue light. ... Cells in culture, stained for keratin (red) and DNA (green). ... Biological tissue is a collection of interconnected cells that perform a similar function within an organism. ... It has been suggested that this article or section be merged into microscope. ... Gene expression, or simply expression, is the process by which a genes DNA sequence is converted into the structures and functions of a cell. ... A fusion protein is a protein created through genetic engineering from two or more proteins/peptides. ...
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