A fusion inhibitor is a class of antiretroviral drugs used to treat viral infections such as HIV. It works by blocking the virus from fusing with a cell's membrane to enter and infect the cell. Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV. Different classes of antiretroviral drugs act at different stages of the HIV life cycle. ... Species Human immunodeficiency virus 1 Human immunodeficiency virus 2 Human immunodeficiency virus (HIV) is a retrovirus that causes acquired immunodeficiency syndrome (AIDS, a condition in humans in which the immune system begins to fail, leading to life-threatening opportunistic infections). ... The cell membrane (also called the plasma membrane, plasmalemma or phospholipid bilayer) is a semipermeable lipid bilayer common to all living cells. ... Viral entry is the earliest stage of infection in the viral life cycle, as the virus comes into contact with the host cell and introduces viral material into the cell. ...
Enfuvirtide
Enfuvirtide, also called T-20, is a fusion inhibitor with the trade name Fuzeon®.
For example, HIV binds to host cell receptor CD4 by the protein gp120. Upon binding GP120 deforms allowing the viral protein gp41 to embed itself into the host cell's plasma membrane, entry inhibitors bind to GP41 preventing the creation of an entry pore for the capsid of the virus keeping it out of the cell. [1] Enfuvirtide is a novel antiretroviral drug used in combination therapy for the treatment of HIV-1 infection. ... CD4 (cluster of differentiation 4) is a molecule that is expressed on the surface of T helper cells (as well as regulatory T cells and dendritic cells). ... An HIV envelope glycoprotein that is anchored to the membrane through non-covalent bonds along with gp41, both coming from a cleaved protein, gp160. ... The genome and proteins of HIV have been the subject of extensive research since the discovery of the virus in 1983. ... A capsid is the outer shell of a virus. ...
It has been found that a component in green tea, EGEC, competes for gp120, and Theaflavins found in black tea competes for gp41 with HIV. Campbeltown Airport (IATA: CAL, ICAO: EGEC) is located 3 nautical miles (5. ... Theaflavins are polyphenols that are formed from catechins in tea leaves during the enzymatic oxidation of tea leaves. ...
T-20 is the first fusioninhibitor -- a newer class of antiretroviral drugs that blocks the virus from attaching to and invading immune cells -- to move to an expanded access program.
T-20 and another fusioninhibitor called T-1249 are part of a "radical new approach" to fighting HIV, which is capable of mutating and developing a resistance to many approved medications.
Fusioninhibitors hold promise, especially for patients with resistant strains of HIV, because they block the fusion process.
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