Gabâ or gabaa, for the Cebuano people (Cebu Island, Philippines), is the concept of a non-human and non-divine, immanent retribution. ... Gaba may refer to: Gabâ or gabaa (Philippines), the concept of negative karma of the Cebuano people GABA, the gamma-amino-butyric acid neurotransmitter GABA receptor, in biology, receptors with GABA as their endogenous ligand Marianne Gaba, a US model and September 1959 Playboy centerfold Pierre Toura Gaba (1920-1998... The GABA receptors are a group of receptors with γ-aminobutyric acid (GABA) as their endogenous ligand. ... Marianne Gaba (born 13 November 1939 in Chicago, Illinois) is an American model. ... Pierre Toura Gaba (1920–1998) was a Chadian politician and diplomat. ...
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GABA is synthesized in the brain from another aminoacid, glutamate, and functions as an inhibitory neurotransmitter meaning that it blocks nerve impulses.
In the body, GABA is concentrated in the hypothalamus region of the brain and is known to play a role in the overall functioning of the pituitary gland which regulates growth hormone synthesis, sleep cycles, and body temperature.
GABA and GHB appear to be readily interconvertible in the brain and a number of chemically related compounds, such as GBL (gamma-butyrolactone), BD (1,4-butanediol) and furanone (2,3H-furanone di-hydro) are rapidly converted in the body into GHB.
GABA's presumed absence in invertebrates was contradicted by the discovery that it was found to be highly concentrated in inhibitory motor neurons of Ascaris (Guastella et al., 1991; Johnson and Stretton, 1987) and crayfish (Kravitz et al., 1963).
GABA is synthesized in the cytoplasm of the neuron by glutamic acid decarboxylase (GAD) encoded by the unc-25 gene.
Bamber, B.A., Richmond, J.E., Otto, J.F., and Jorgensen, E.M. The composition of the GABA receptor at the Caenorhabditis elegans neuromuscular junction.
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