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Encyclopedia > Galantamine

Galantamine chemical structure
Galantamine Galantamine molecular structure I, the creator of this image, hereby release it into the public domain. ...

(4aS,6R,8aS)-4a,5,9,10,11,12-
hexahydro-3-methoxy-11-methyl-6H-
benzofuro(3a,3,2-ef)(2)benzazepin-6-ol
CAS number
357-70-0
ATC code
N06DA04
Chemical formula C17H21NO3
Molecular weight 287.357
Bioavailability  ?
Metabolism liver partially CYP450:2D6/3A4 substrate
Elimination half-life 7 hours
Excretion urine 95% (32%unchanged) feces 5%
Pregnancy category B
Legal status  ?
Routes of administration  ?

Galantamine (trade name Razadyne®) is a medication used in the treatment of Alzheimer's disease. CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... --212. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ... The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ...


Galantamine is mostly used as hydrobromide salt. It is a centrally acting reversible cholinesterase inhibitor in the same class as donepezil. Galantamine has a much shorter half life than donepezil (there is a newer prolonged release version available in 2004) and it also has more nicotinic receptor activity and is potentially more stimulating but also probably because of this activity tends to cause worse gastrointesinal side effects. Hydrobromic Acid is a chemical compound, with the chemical formula HBr. ... Acetylcholinesterase In biochemistry, cholinesterase is a term which refers to one of the two enzymes: Acetylcholinesterase (EC 3. ... Donepezil, which goes by the trade name Aricept® (Pfizer), is a centrally acting reversible cholinesterase inhibitor. ... Half-Life is a science fiction first-person shooter computer game developed by Valve Software and published by Sierra Entertainment in 1998, based on a heavily-modified Quake game engine. ... Nicotinic Receptors form ion channels present in the plasma membrane of cells. ...


  Results from FactBites:
 
Galantamine articles and Alzheimer's research (784 words)
Galantamine is different from donepezil (Aricept®) and rivastigmine (Exelon®) in one very important way, galantamine has the unique ability to increase the receptiveness of nicotinic receptors to acetylcholine continue
efficacy of galantamine in dementia and Alzheimer's disease
Galantamine is an attractive option for patients with Alzheimer's disease who have not benefited from their current therapy.
Galantamine - Wikipedia, the free encyclopedia (616 words)
Galantamine in its pure form is a white powder.
Galantamine is a competitive and reversible cholinesterase inhibitor.
Galantamine is indicated for mild to moderate dementia of the Alzheimer’s type.
  More results at FactBites »


 

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