Gamma glutamyl transferase (GGT or GGTP, or Gamma-GT) (EC 2.3.2.2) is a liverenzyme. The enzyme is also present in other tissues, such as the epididymis. Its level in the blood may be tested for, as an elevated level may indicate an abnormality in the liver, though this can be caused by a number of conditions including: EC numbers (Enzyme Commission numbers) are a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ... The liver is the largest internal organ in the human body. ... Ribbon diagram of the enzyme TIM. TIM is catalytically perfect, meaning its conversion rate is limited, or nearly limited to its substrate diffusion rate. ... Male Anatomy The epididymis is part of the human male reproductive system and is present in all male mammals. ...
Its levels are increased in chronic and acute alcohol abuse. Congestive heart failure (CHF), also called congestive cardiac failure (CCF) or just heart failure, is a condition that can result from any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. ... In medicine, cholestasis is a condition where bile cannot flow from the liver to the duodenum. ... Cirrhosis is a chronic disease of the liver in which liver tissue is replaced by connective tissue, resulting in the loss of liver function. ... In medicine, ischemia (Greek ισχαιμία, isch- is restriction, hema or haema is blood) is a restriction in blood supply, generally due to factors in the blood vessels, with resultant damage or dysfunction of tissue. ... Necrosis (in Greek ÎεκÏός = Dead) is the name given to unprogrammed death of cells/living tissue (compare with apoptosis - programmed cell death). ... Tumor (American English) or tumour (British English) originally means swelling, and is sometimes still used with that meaning. ... Hepatitis is a gastroenterological disease, featuring inflammation of the liver. ... Hepatotoxicity (from hepatic toxicity) is chemical-driven liver damage. ... This article needs cleanup. ...
GGT activity was highest in cultures from cauda epididymis, both in conditioned media and cell fractions, while GST activity did not show regional differences in conditioned media, but exhibited higher activity in cell homogenates from cauda cultures than those obtained from corpus and caput epididymis.
Normal GGT activity was observed in all nine amniotic fluid samples from pregnancies with fetuses affected with different forms of inborn errors of metabolism diseases, in the two pregnancies with hemophilia A and in the pregnancy with a male fetus with fragile X syndrome.
GGT is present in embryonic yolk sac and its activity increases with gestational age, suggesting that the developing embryo might be at risk from maternal exposure to glutathione conjugates or compounds which are shown to form glutathione conjugates.
This test is used to detect diseases of the liver, bile ducts, and kidney; and to differentiate liver or bile duct (hepatobiliary) disorders from bone disease.
GGT participates in the transfer of amino acids across the cellular membrane and in glutathione metabolism.
In particular, ALP is increased in hepatobiliary disease and bone disease.
Feeds |
Contact