A gammaretrovirus is a genus of the retroviridaefamily. Many species contain oncogenes and cause sarcomas and leukemias. See genus (mathematics) for the use of the term in mathematics. ... Genera Alpharetrovirus Betaretrovirus Gammaretrovirus Deltaretrovirus Epsilonretrovirus Lentivirus Spumavirus A retrovirus is a virus which has a genome consisting of two identical plus sense RNA molecules. ... Scientific classification or biological classification refers to how biologists group and categorize extinct and living species of organisms. ... An oncogene is a gene that can cause a cell to develop into a tumor cell, possibly resulting in cancer. ... A sarcoma is a cancer of the bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue. ... Leukemia (leukaemia in Commonwealth English) is a group of blood diseases characterized by malignancies (cancer) of the blood-forming tissues. ...
Examples are the murine leukemia virus, the feline leukemia virus, the feline sarcoma virus, and the avian reticuloendotheliosis viruses. Feline leukemia virus (FeLV) is a retrovirus, a virus in which genetic information is contained in RNA instead of DNA. All retroviruses, including feline immunodeficiency virus (FIV) and human immunodeficiency virus (HIV), produce an enzyme called reverse transcriptase. ...
Silencing and variegation of gammaretrovirus and lentivirus vectors.
The koala retrovirus (KoRV) is a gammaretrovirus closely related to the gibbon ape leukemia virus and induces leukemias and immune deficiencies associated with opportunistic infections, such as chlamydiosis.
Feline leukemia virus (FeLV), Gammaretrovirus, and feline immunodeficiency virus, a Lentivirus, are members of the familyRetroviridae, and may establish persistent infections in the domestic cat (Felis catus).
The vector was derived from a murine gammaretrovirus, a member of the Retroviridaefamily.
Gammaretrovirus vectors integrate into the host genome, potentially resulting in long-term expression of the therapeutic gene for the life of the transduced cells and their progeny.
However, one limitation to the use of gammaretroviral vectors is that they do not transduce non-dividing cells, such as macrophages, resting T lymphocytes, unstimulated hematopoietic stem cells, or neurons.
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