Gardner's syndrome is a genetic disorder characterized by the presence of multiple polyps in the colon together with tumors outside the colon. The extracolonic tumors may include osteomas of the skull, thyroid cancer, epidermoid cysts, fibromas and sebaceous cysts. The countless polyps in the colon predispose to the development of colon cancer. DNA, the molecular basis for inheritance. ... Colon has several meanings: colon (anatomy) colon (punctuation) colon (rhetoric) See also Colón This is a disambiguation page — a navigational aid which lists other pages that might otherwise share the same title. ... An osteoma is a new piece of bone growing on another piece, typically the skull. ... Thyroid cancer is cancer of the thyroid gland. ... An epidermoid cyst is a benign cyst, developed out of ectodermal tissue. ... Soft Fibroma (fibroma molle). ... Schematic view of a hair follicle with sebaceous gland. ... A cyst is a closed sac having a distinct membrane and developing abnormally in a cavity or structure of the body. ... This article is about the cnidarian polyps. ... Diagram of the stomach, colon, and rectum Colorectal cancer includes cancerous growths in the colon, rectum and appendix. ...

Gardner's syndrome is inherited in an autosomal dominant manner. Typically, one parent has Gardner's syndrome. Each of their children, male and female alike, are at 50% risk of inheriting the gene for Gardner's syndrome and manifesting it. It has been suggested that this article or section be merged into Dominance relationship. ...

Gardner's syndrome is inherited in an autosomal dominant fashion.

Gardner's syndrome can be identified based on oral findings, including multiple impacted and supernumerary teeth, multiple jaw osteomas which give a "cotton-wool" appearance to the jaws, as well as multiple odontomas. Image File history File links Autosomal_Dominant_Pedigree_Chart. ... Image File history File links Autosomal_Dominant_Pedigree_Chart. ... In dentistry, hyperdontia is the condition of having supernumerary teeth, teeth which appear in addition to the regular number of teeth. ...

The syndrome is named for Eldon J. Gardner (1909-1989), a college teacher of genetics, who first described it in 1951. Gardner had been introduced to a large Utah family with the syndrome by a premedical student in his course in genetics. Official language(s) English Capital Salt Lake City Largest city Salt Lake City Area  Ranked 13th  - Total 84,876 sq mi (219,887 km²)  - Width 270 miles (435 km)  - Length 350 miles (565 km)  - % water 3. ...

Gardner's syndrome is now known to be caused by mutation in the APC gene located in chromosome 5q21 (band q21 on chromosome 5). This is the same gene as is mutant in familial adenomatous polyposis (FAP), a more common disease that also predisposes to colon cancer. It has been suggested that mutant be merged into this article or section. ... Familial adenomatous polyposis (FAP) is an inherited condition in which numerous polyps to form in the epithelium of the large intestine. ... Figure 1: A representation of a condensed eukaryotic chromosome, as seen during cell division. ... Familial adenomatous polyposis (FAP) is an inherited condition in which numerous polyps form mainly in the epithelium of the large intestine. ...

New genetic and molecular information has caused some genetic disorders to be split into multiple entities while other genetic disorders merge into one condition. After existing for most of the second half of the 20th century, Gardner's syndrome has vanished as a separate entity. It has been merged into familial adenomatous polyposis (FAP) and is now considered simply a phenotypic variant of FAP. The phenotype of an individual organism is either its total physical appearance and constitution, or a specific manifestation of a trait, such as size or eye color, that varies between individuals. ... Variant may refer to: Look up variant in Wiktionary, the free dictionary. ...

Reference

• Gardner, EJ: A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum. Am J Hum Genet 3: 167-176, 1951. (The original report of Gardner's syndrome in the American Journal of Human Genetics.)

Since its inception in 1948, The American Journal of Human Genetics has provided a record of research and review relating to heredity in humans and to the application of genetic principles in medicine and public policy, as well as in related areas of molecular and cell biology. ...

External links

• Entry to Adenomatous polyposis of the colon; APC, Gardner syndrome included in OMIM (Online Mendelian Inheritance in Man), a comprehensive compendium of knowledge