Gatifloxacin
Systematic (IUPAC) name
1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid
Identifiers
CAS number	112811-59-3
ATC code	J01MA16 S01AX21
PubChem	5379
DrugBank	APRD00996
Chemical data
Formula	C19H22FN3O4
Mol. weight	375.394 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	20%
Metabolism	?
Half life	7-14 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	?
Routes	?

Gatifloxacin is an antibiotic of the fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and Topoisomerase IV. Bristol-Myers Squibb introduced Gatifloxacin in 1999 under the proprietary name Tequin for the treatment of respiratory tract infections, having licensed the medication from Kyorin Pharmaceutical Company of Japan. Allergan produces an eye-drop formulation called Zymar. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. Image File history File links Gatifloxacin_structure. ... IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... You may be looking for albumen, or egg white. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος (metabolismos)) is the biochemical modification of chemical compounds in living organisms anggjgjhnd cell (b). ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ... The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... An antibiotic is a drug that kills or slows the growth of bacteria. ... Quinolones and fluoroquinolones form a group of broad-spectrum antibiotics. ... Subgroups Actinobacteria Aquificae Bacteroidetes/Chlorobi Chlamydiae/Verrucomicrobia Chloroflexi Chrysiogenetes Cyanobacteria Deferribacteres Deinococcus-Thermus Dictyoglomi Fibrobacteres/Acidobacteria Firmicutes Fusobacteria Gemmatimonadetes Nitrospirae Planctomycetes Proteobacteria Spirochaetes Thermodesulfobacteria Thermomicrobia Thermotogae Bacteria (singular: bacterium) are a major group of living organisms. ... Ribbon diagram of the enzyme TIM. TIM is catalytically perfect, meaning its conversion rate is limited, or nearly limited to its substrate diffusion rate. ... DNA gyrase, also called gyrase, is an enzyme in the topoisomerase family that passes one double strand of DNA through another double strand of DNA. Because gyrase changes the linking number of the DNA by two in each enzymatic step, it is classified as a type II topoisomerase. ... Topoisomerase IV is one of two type-II topoisomerases in bacteria, the other being DNA gyrase. ... Bristol-Myers Squibb (NYSE: BMY), colloquially referred to as BMS, is a pharmaceutical corporation, formed by a 1989 merger between pharmaceutical companies Bristol-Myers Company and Squibb Corporation. ... 1999 (MCMXCIX) was a common year starting on Friday, and was designated the International Year of Older Persons by the United Nations. ... Proprietary indicates that a party exercises private ownership, control or use over an item of property, usually to the exclusion of other parties. ... Common disk-shaped tablets A pharmacological tablet is a medicinal or other active substance mixed with binder powders and pressed into a tablet form. ... Drinking water This article focuses on water as we experience it every day. ... An intravenous drip in a hospital Intravenous therapy or IV therapy is the administration of liquid substances directly into a vein. ...

Side-effects and removal from the market

A Canadian study published in the New England Journal of Medicine in March 2006 claims Tequin can have "life threatening" side effects including serious diabetes.^[1] An editorial by Dr. Jerry Gurwitz in the same issue called for the Food and Drug Administration (FDA) to consider giving Tequin a black box warning.^[2] This editorial followed distribution of a letter dated February 15 by Bristol-Myers Squibb to health care providers indicating action taken with the FDA to strengthen warnings for the medication.^[3] Subsequently it was reported on May 1, 2006 that Bristol-Myers Squibb would stop manufacture of Tequin, end sales of the drug after existing stockpiles were exhausted, and return all rights to Kyorin.^[4] The New England Journal of Medicine (NEJM) is a peer-reviewed medical journal published by the Massachusetts Medical Society with the highest impact factor for a general medical journal. ... An adverse drug reaction (abbreviated ADR) is a term to describe the unwanted, negative consequences sometimes associated with the use of medications. ... This article is about the disease that features high blood sugar. ... An editorial is a statement or article by a news organization (generally a newspaper) that expresses an opinion rather than attempting to simply report news, as the latter should ideally be done without bias. ... This article or section is in need of attention from an expert on the subject. ... In the United States, a black box warning is a type of warning that appears on prescription drugs that may cause serious side effects. ...

Notes

1. ^ Park-Wyllie, Laura Y., David N. Juurlink, Alexander Kopp, Baiju R. Shah, Therese A. Stukel, Carmine Stumpo, Linda Dresser, Donald E. Low, Muhammad M. Mamdani (March 2006). "Outpatient Gatifloxacin Therapy and Dysglycemia in Older Adults". The New England Journal of Medicine 354 (13): 1352–1361. PMID 16510739. Retrieved on 2006-05-01. Note: publication date 30 March; available on-line 1 March
2. ^ Gurwitz, Jerry H. (March 2006). "Serious Adverse Drug Effects — Seeing the Trees through the Forest". The New England Journal of Medicine 354 (13): 1413–1415. PMID 16510740. Retrieved on 2006-05-01.
3. ^ Lewis-Hall, Freda (February 15, 2006). Dear Healthcare Provider:. (PDF) Bristol-Myers Squibb. Retrieved on May 1, 2006.
4. ^ Schmid, Randolph E., "Drug Company Taking Tequin Off Market", Associated Press, May 1, 2006. Retrieved on May 1, 2006.

The New England Journal of Medicine (NEJM) is a peer-reviewed medical journal published by the Massachusetts Medical Society. ... 2006 (MMVI) is a common year starting on Sunday of the Gregorian calendar. ... May 1 is the 121st day of the year in the Gregorian calendar (122nd in leap years). ... The New England Journal of Medicine (NEJM) is a peer-reviewed medical journal published by the Massachusetts Medical Society. ... 2006 (MMVI) is a common year starting on Sunday of the Gregorian calendar. ... May 1 is the 121st day of the year in the Gregorian calendar (122nd in leap years). ... May 1 is the 121st day of the year in the Gregorian calendar (122nd in leap years). ... 2006 (MMVI) is a common year starting on Sunday of the Gregorian calendar. ... Associated Press logo The Associated Press, or AP, is an American news agency, the worlds largest such organization. ...

External links

• Tequin home page