Building 32, one of Genentech headquarters' newer buildings, is located on the San Francisco Bay in South San Francisco, California

Genentech Inc. (NYSE: DNA), a composite of Genetic Engineering Technology, Inc., is a leading biotechnology corporation, which was founded in 1976 by venture capitalist Robert A. Swanson and biochemist Dr. Herbert W. Boyer.^[1][2] It is considered to have founded the biotechnology industry.^[1][2] One of its founders, Boyer, is considered to be one of the pioneers in the field of recombinant DNA technology (the company's ticker symbol reflects Boyer's contribution to the field). Boyer with a fellow researcher, Stanley Norman Cohen, in 1973, invented recombinant genetic engineering, by realizing that restriction enzymes could be used as "scissors" to cut DNA fragments of interest from one source, to be ligated into a similarly cut plasmid vector. While Cohen returned to the laboratory in academia,^[1] Robert Swanson contacted Boyer^[3] to found the company.^[1] Boyer worked with Arthur Riggs and Keiichi Itakura from the Beckman Research Institute, and the group became the first to successfully express a human gene in bacteria when they produced the hormone somatostatin in 1977. David Goeddel and Dennis Kleid were then added to the group, and contributed to its success with insulin in 1978. This article does not cite any references or sources. ... Year 1976 (MCMLXXVI) was a leap year starting on Thursday (link will display full calendar) of the Gregorian calendar. ... The South San Francisco The Industrial City sign A Genentech-sponsored sign declaring South San Francisco to be the Birthplace of Biotechnology. ... Motto: (traditional) In God We Trust (official, 1956–present) Anthem: The Star-Spangled Banner Capital Washington, D.C. Largest city New York City Official language(s) None at the federal level; English de facto Government Federal Republic  - President George W. Bush (R)  - Vice President Dick Cheney (R) Independence - Declared - Recognized... Arthur D. Levinson (born March 31, 1950 in Seattle, Washington) is President and Chief Executive Officer of Genentech. ... Insulin crystals Biotechnology is technology based on biology, especially when used in agriculture, food science, and medicine. ... Growth hormone Growth hormone is a polypeptide hormone synthesised and secreted by the anterior pituitary gland which stimulates growth and cell reproduction in humans and other vertebrate animals. ... Pulmozyme® (dornase alfa) is a highly purified solution of recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Pulmozyme hydrolyzes the DNA in sputum/mucus of CF patients and reduces viscoelasticity in the lungs, promoting improved clearance of secretions. ... Rituximab, sold under the trade names Rituxan® and Mabthera®, is a monoclonal antibody used in the treatment of B cell non-Hodgkins lymphoma, a kind of cancer. ... Herceptin (or Trastuzumab) is an anti-cancer therapy that acts on the erbB2 receptor. ... Omalizumab (marketed under the name Xolair®) is the generic name for a drug used mainly in allergy-related asthma therapy, with the purpose of reducing allergic hypersensitivity. ... ... Bevacizumab is an anti-angiogenesis drug used in treatment of cancer. ... Erlotinib hydrochloride (Tarceva®, Genentech/OSIP) is a drug used to treat non-small cell lung cancer and in clinical trials for several other types of cancer. ... Ranibizumab (trade name Lucentis) is a monoclonal antibody fragment derived from the same parent murine antibody as bevacizumab (Avastin). ... For the tax agency in Ireland of the same name, see Revenue Commissioners. ... USD redirects here. ... Year 2006 (MMVI) was a common year starting on Sunday of the Gregorian calendar. ... Net income is equal to the income that a firm has after subtracting costs and expenses from the total revenue. ... USD redirects here. ... Year 2006 (MMVI) was a common year starting on Sunday of the Gregorian calendar. ... This article is about work. ... A website (alternatively, web site or Web site) is a collection of Web pages, images, videos or other digital assets that is hosted on one or more web servers, usually accessible via the Internet. ... The New York Stock Exchange (NYSE), nicknamed the Big Board, is a New York City-based stock exchange. ... Insulin crystals Biotechnology is technology based on biology, especially when used in agriculture, food science, and medicine. ... For other uses, see Corporation (disambiguation). ... Year 1976 (MCMLXXVI) was a leap year starting on Thursday (link will display full calendar) of the Gregorian calendar. ... Robert A Swanson was the founder of Genentech, one of the leading biotech companies in the country and a pioneer of the industry. ... Herbert (Herb) Boyer (born 1936) is a Co-recipient of the 1996 Lemelson-MIT Prize and a co-founder of Genentech. ... Insulin crystals Biotechnology is technology based on biology, especially when used in agriculture, food science, and medicine. ... Recombinant DNA technology adds/replaces DNA in an organism resulting in the recipient organism containing exogenous DNA. Recombinant proteins are proteins that are produced by different genetically modified organisms following insertion of the relevant DNA into their genome. ... A stock symbol or ticker symbol is a mnemonic used to uniquely identify publicly-traded shares of a corporation on a particular stock market. ... Stanley Norman Cohen is an American geneticist. ... For the song by James Blunt, see 1973 (song). ... Robert Swanson was a researcher and developer, and is credited with the invention of the first six- and five-chime air horn for use on locomotives. ... Dr. Arthur Riggs, Ph. ... The Beckman Research Institute (BRI) is a research facility in Los Angeles. ... Gene expression, or simply expression, is the process by which the inheritable information which comprises a gene, such as the DNA sequence, is made manifest as a physical and biologically functional gene product, such as protein or RNA. Several steps in the gene expression process may be modulated, including the... For other uses, see Gene (disambiguation). ... Phyla Actinobacteria Aquificae Chlamydiae Bacteroidetes/Chlorobi Chloroflexi Chrysiogenetes Cyanobacteria Deferribacteres Deinococcus-Thermus Dictyoglomi Fibrobacteres/Acidobacteria Firmicutes Fusobacteria Gemmatimonadetes Lentisphaerae Nitrospirae Planctomycetes Proteobacteria Spirochaetes Thermodesulfobacteria Thermomicrobia Thermotogae Verrucomicrobia Bacteria (singular: bacterium) are unicellular microorganisms. ... For other uses, see Hormone (disambiguation). ... Somatostatin is a hormone. ... Also: 1977 (album) by Ash. ... The introduction to this article provides insufficient context for those unfamiliar with the subject matter. ... Not to be confused with inulin. ... Year 1978 (MCMLXXVIII) was a common year starting on Sunday (link displays the 1978 Gregorian calendar). ...

As of March 2008, Genentech employs more than 11,000 people and Arthur D. Levinson is the Chairman and CEO.^[4] The Swiss pharmaceutical conglomerate Hoffmann-La Roche owns the majority of Genentech shares [1]. Arthur D. Levinson (born March 31, 1950 in Seattle, Washington) is President and Chief Executive Officer of Genentech. ... Hoffmann-La Roche, Ltd. ...

Product Timeline

• 1982 - Synthetic "human" insulin approved by the U.S. Food and Drug Administration (FDA), thanks largely to its partnership with insulin manufacturer Eli Lilly and Company, who shepherded the product through the FDA approval process. The product (Humulin) was licensed to and manufactured by Lilly, and was the first-ever approved genetically engineered human therapeutic.
• 1985 - Protropin (somatrem) - Supplementary growth hormone for children with growth hormone deficiency (ceased manufacturing December 2002).
• 1987 - Activase (recombinant tissue plasminogen activator)- To dissolve blood clots in patients with acute myocardial infarction. Also used to treat non-hemorrhagic stroke.
• 1990 - Actimmune (interferon gamma 1b) - Treatment of chronic granulomatous disease (licensed to Intermune).
• 1993 - Nutropin (recombinant somatropin) - Growth hormone for children and adults for treatment before kidney transplant due to chronic renal insufficiency.
• 1994 - Pulmozyme (dornase alfa) - Inhalation treatment for children and young adults with cystic fibrosis - recombinant DNAse.
• 1997 - Rituxan (rituximab)- Treatment for specific kinds of non-Hodgkins lymphomas.
• 1998 - Herceptin (trastuzumab) - Treatment for metastatic breast cancer patients with tumors that overexpress the HER2 gene. Recently approved for adjuvant therapy for breast cancer.
• 2000 - TNKase (tenecteplase) - "Clot-busting" drug to treat acute myocardial infarction.
• 2003 - Xolair (omalizumab) - Subcutaneous injection for moderate to severe persistent asthma.
• 2003 - Raptiva (efalizumab) - Antibody designed to block the activation and reactivation of T cells that lead to the development of psoriasis. Developed in partnership with XOMA
• 2004 - Avastin (bevacizumab) - Anti-VEGF monoclonal antibody for the treatment of metastatic cancer of the colon or rectum.
• 2004 - Tarceva (erlotinib) - Treatment for patients with locally advanced or metastatic non-small cell lung cancer, and pancreatic cancer.
• 2006 - Lucentis (ranibizumab injection) - The U.S. Food and Drug Administration (FDA) has approved LUCENTIS(TM) (ranibizumab injection) for the treatment of neovascular (wet) age-related macular degeneration (AMD). The FDA approved LUCENTIS after a Priority Review (six-month). Genentech started shipping product on June 30, 2006, the day the product was approved.

Not to be confused with inulin. ... The United States Food and Drug Administration is the government agency responsible for regulating food, dietary supplements, drugs, cosmetics, medical devices, biologics and blood products in the United States. ... Eli Lilly and Company (NYSE: LLY) is a global pharmaceutical company and one of the worlds largest corporations. ... Growth hormone (GH) or somatotropin (STH) is a protein hormone which stimulates growth and cell reproduction in humans and other animals. ... Growth Hormone Deficiency is the medical condition of inadequate production of growth hormone (GH) and its effects on children and adults. ... In blood coagulation, tissue plasminogen activator (tPA) is an enzyme (EC 3. ... Heart attack redirects here. ... Interferons (IFNs) are natural proteins produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, bacteria, parasites and tumor cells. ... Chronic granulomatous disease (CGD) is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly, the superoxide radical) used to kill certain ingested pathogens. ... Growth hormone Growth hormone is a polypeptide hormone synthesised and secreted by the anterior pituitary gland which stimulates growth and cell reproduction in humans and other vertebrate animals. ... Growth hormone (GH) or somatotropin (STH) is a protein hormone which stimulates growth and cell reproduction in humans and other animals. ... Pulmozyme® (dornase alfa) is a highly purified solution of recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Pulmozyme hydrolyzes the DNA in sputum/mucus of CF patients and reduces viscoelasticity in the lungs, promoting improved clearance of secretions. ... A deoxyribonuclease (DNase, for short) is any enzyme that catalyzes the hydrolytic cleavage of phosphodiester linkages in the DNA backbone. ... Rituximab, sold under the trade names Rituxan® and MabThera®, is a monoclonal antibody used in the treatment of B cell non-Hodgkins lymphoma, B cell leukemia, and some autoimmune disorders. ... Lymphoma is a general term for cancers that develop in the lymphatic system. ... Trastuzumab (more commonly known under the trade name Herceptin) is a humanized monoclonal antibody that acts on the HER2/neu (erbB2) receptor. ... Breast cancer is cancer of breast tissue. ... Thrombolysis is the breakdown (lysis) by pharmacological means, of blood clots. ... Heart attack redirects here. ... Omalizumab (marketed under the name Xolair®) is a monoclonal antibody made by Genentech / Novartis and used mainly in allergy-related asthma therapy, with the purpose of reducing allergic hypersensitivity. ... Efalizumab (Raptiva®, Genentech) is a medication used to treat psoriasis. ... Each antibody binds to a specific antigen; an interaction similar to a lock and key. ... T cells are a subset of lymphocytes that play a large role in the immune response. ... Bevacizumab (trade name Avastin) is a monoclonal antibody against vascular endothelial growth factor. ... Cancer is a class of diseases or disorders characterized by uncontrolled division of cells and the ability of these to spread, either by direct growth into adjacent tissue through invasion, or by implantation into distant sites by metastasis (where cancer cells are transported through the bloodstream or lymphatic system). ... It has been suggested that this article or section be merged with Large intestine. ... The rectum (from the Latin rectum intestinum, meaning straight intestine) is the final straight portion of the large intestine in some mammals, and the gut in others, terminating in the anus. ... Erlotinib hydrochloride (trade name Tarceva, Genentech/OSIP, originally coded as OSI-774) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. ... Lung cancer is a disease of uncontrolled cell growth in tissues of the lung. ... Ranibizumab is a fragment of the Bevacizumab (Avastin) FAB fragment. ... is the 181st day of the year (182nd in leap years) in the Gregorian calendar. ... Year 2006 (MMVI) was a common year starting on Sunday of the Gregorian calendar. ...

Awards and Recognitions

• Genentech was named one of the 100 Best Companies for Working Mothers in 2004, 2006 and 2007 by Working Mother Magazine..
• It was named as one of the 100 best corporate citizens 2005 by the Business Ethics Magazine^[5]
• Fortune Magazine named Genentech number one on its 2006 list of the "100 Best Companies To Work For." This was the first number one ranking for the company. In 2007, it dropped to second place, behind Google. The company has been named to the list for nine consecutive years. The ranking is based on anonymous employee responses to a survey as well as an evaluation of the company's policies and culture.
• Genentech was named Top Employer by Science Magazine on October 15, 2007, where it has been recognized for six consecutive years.
• Also in October 2007, Genentech was named Most Admired Biotech Company as well as most admired Pharmaceutical company in Fortune in 2008.

Categories: Magazines stubs | Time Warner subsidiaries | Business magazines ... is the 288th day of the year (289th in leap years) in the Gregorian calendar. ... Year 2007 (MMVII) was a common year starting on Monday of the Gregorian calendar in the 21st century. ...

Facility locations

Genentech's corporate headquarters is at South San Francisco, California, with additional manufacturing facilities in Vacaville, California. In June 2005, Genentech purchased Biogen Idec's manufacturing facility in Oceanside, California. On March 17, 2006, Genentech announced its decision to construct a new manufacturing facility in Hillsboro, Oregon which is expected to be operational by 2010. In December 2006, Genentech sold its Porrino, Spain facility to Lonza and acquired an exclusive right to purchase Lonza's manufacturing facility under construction in Singapore. The South San Francisco The Industrial City sign A Genentech-sponsored sign declaring South San Francisco to be the Birthplace of Biotechnology. ... Vaca Mountains during summer Vacaville, California is located in Solano County, California, United States, between Sacramento and San Francisco. ... Biogen Idec, Inc. ... Oceanside is the third largest city in San Diego County, California. ... is the 76th day of the year (77th in leap years) in the Gregorian calendar. ... Year 2006 (MMVI) was a common year starting on Sunday of the Gregorian calendar. ... Nickname: Location of Hillsboro in the state of Oregon Coordinates: , County Washington County Incorporated 1876 Government  - Mayor Tom Hughes Area  - City 58. ...

Disputes

In 1999, Genentech agreed to pay the University of California, San Francisco $200 million to settle a nine-year-old patent dispute. In 1990, UCSF sued Genentech for $400 million in compensation for alleged theft of technology developed at the university and covered by a 1982 patent. Genentech claimed that they developed Protropin, a growth hormone, independently of UCSF. A jury ruled that the university's patent was valid last July, but wasn't able to decide whether Protropin was based upon UCSF research or not. Protropin, a drug used to treat dwarfism, was Genentech's first marketed drug and its $2 billion in sales has contributed greatly to Genentech's position as an industry leader. The settlement was to be divided as follows: $30 million to the University of California General Fund, $85 million to the three inventors and two collaborating scientists, $50 million towards a new teaching and research campus for UCSF, and $35 million to support university-wide research. The University of California, San Francisco (UCSF) is one of the worlds leading centers of health sciences research, patient care, and education. ...

Research

Genentech markets itself as a research-driven corporation that follows the science to make new innovations. They employ more than 700 scientists and cover a wide range of scientific activity - from molecular biology to protein chemistry to bioinformatics and physiology. Genentech scientists in these various areas of expertise currently focus their efforts on three disease categories: Oncology, Immunology, and Tissue Growth and Repair. Genentech recent hiring and acquisitions indicate an intent to expand into Microbiology, Medical Imaging, and Neuroscience divisions. Genentech research facilities are located only on the South San Francisco campus.

References

Corporate Chronology. Genentech Inc.. Retrieved on May 30, 2005. Year 2003 (MMIII) was a common year starting on Wednesday of the Gregorian calendar. ... is the 23rd day of the year in the Gregorian calendar. ... Nature is a prominent scientific journal, first published on 4 November 1869. ... Not to be confused with Public Broadcasting Services in Malta. ... 2008 (MMVIII) is the current year, a leap year that started on Tuesday of the Anno Domini (or common era), in accordance to the Gregorian calendar. ... is the 125th day of the year (126th in leap years) in the Gregorian calendar. ... Year 2005 (MMV) was a common year starting on Saturday (link displays full calendar) of the Gregorian calendar. ...

External links

• Official website
• Human Growth Hormone Glossary
• A Cancer Drug Shows Promise, at a Price That Many Can't Pay New York Times, February 15, 2006, Alex Berenson
• Presentation by Genentech employees about Sustainable Business January 10, 2007