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Studies concerning genetic association aim testing whether single-locus allele or genotype frequencies (or more generally, multilocus haplotype frequencies) are different between 2 groups (usually diseased subjects and healthy controls). Genetic association studies are based on the principle that genotypes are measured "directly", i.e. by sequencing the actual genetic code.
Lack of association of genetic polymorphisms in the interleukin-1beta interleukin-1 receptor antagonist interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese.
Association of interleukin-1 receptor antagonist gene polymorphism with IgA nephropathy.
Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-alpha IL-1beta and IL-1Ra genes.
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