The Ghetto Brothers were a gang (or club) founded in New York City's South Bronx in the late 1960s. They eventually spread to much of the Northeastern United States. Like the Young Lords, they were involved in Puerto Rican nationalism, including, in the case of the Ghetto Brothers, an association with the then-new Puerto Rican Socialist Party.

Ghetto Brothers founder Benjamin Melendez, who left the organization in 1976, was also known as a guitarist. He led a band, also known as the Ghetto Brothers, which included his late brother Victor Melendez on drums. They released one (self-titled) album in 1972, which had only informal, local distribution.

The Ghetto Brothers, especially in their early years, had a reputation as one of the more politically minded and less vengeful of New York-area gangs. After Cornell "Black Benjy" Benjamin was killed in 1971 trying to prevent a fight between two rival gangs, the Ghetto Brothers did not seek the expected revenge on those responsible for his death. Instead, under Melendez's leadership (and that of Carlos Suarez, a.k.a Carlos Melendez), they were instrumental in achieving a moderately successful truce among South Bronx and other New York-area gangs. The best-known of the meetings to hammer out a peace treaty occurred December 8, 1971. Among those present was Afrika Bambaataa, then a 14-year-old Black Spade warlord known on the streets as Bambaataa.

Current as of 2004 Hartford, Connecticut mayor Eddie Perez was a member of the Ghetto Brothers when young.

The name Ghetto Brothers was also appropriated by an unrelated 1990s musical group featuring Orlando Voorn and Blake Baxter.