Glen Iris (postcode 3146) is a suburb of Melbourne, Australia. It is split between two local municipalities: roughly three quarters lies in the City of Boroondara, and the other quarter lies in the City of Stonnington.

The division between the two municipalities follows the course of Gardiners Creek, which is a tributary of the Yarra River. A tributary of Gardiners Creek running north through the suburb, Back Creek, has largely been turned into a drain. Also roughly following the course of Gardiners Creek is the Monash Freeway, and the Glen Waverley train line.

Two train stations on the Glen Waverley line, Gardiner and Glen Iris, lie within the suburb. Passing through the eastern part of Glen Iris is the Alamein train line, with Burwood station also within the boundaries of the suburb. (Glen Iris did not originally cover this far east, and this station and its surrounds were originally in the suburb of Burwood). Residents are also served by the numbers 6 and 72 tram routes, as well as the numbers 612 and 734 bus routes.

Glen Iris lies 11 km roughly to the east of the central business district. It is also Melbourne's demographic centre, as the city's urban sprawl spreads further to the east of the city than to the west.

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