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Infantile gliosis (ingls), a New Spontaneous Mutation in the Mouse.
Gliosis does not occur, however, in three reported types of spongiform encephalopathy of mice, gray tremor (21), mahogany (22) and the superoxide dysmutase 2 knockout mouse (23).
If indeed hydrocephalus, vacuolization and gliosis are independent of one other, as appears to be true in these mutants, then the three distinct pathologic changes constitute the pleiotropic effects of a single gene mutation or the effects of a mutational deletion of two or more closely linked genes.
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