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Boehringer Ingelheim News - Heinrich Wieland Prize 2006 awarded for excellence in glycolipid chemistry (419 words) |
 | Ingelheim and Munich/Germany, 03 November 2006 - Professor Alois Fuerstner from the Max-Planck-Institute for Coal Research in Muelheim/Ruhr received this yearÂ’s Heinrich Wieland Prize for exceptional achievements in the synthesis of glycolipids. |
| His work was awarded with the Heinrich Wieland Prize for its contribution to make synthetic approaches to this class of molecule possible. |
| These findings are noteworthy, since they open up the field of biological evaluation of glycolipids for potential therapeutic effects. |
| LIPID RAFTS IN GLYCOLIPID STORAGE DISEASES (770 words) |
| The consequences of glycolipid storage on the proteome of lysosomes and late endosomes. |
| Glycolipid storage diseases have varying degrees of central nervous system involvement and in Tay-Sachs and Sandhoff diseases the neuropathology is very severe and frequently lethal in early infancy. |
| However, since in the glycolipid storage diseases specific glycolipids accumulate in the lysosome it is speculated that these may form a raft which sequesters raft-associated proteins and they are degraded instead of performing their normal function. |
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