In medicine (anatomical pathology), a granuloma is a group of epithelioid macrophages surrounded by a lymphocyte cuff. Granulomas are small nodules that are seen in a variety of diseases such as Crohn's disease, tuberculosis, sarcoidosis, berylliosis and syphilis. It is also a feature of Wegener's granulomatosis and Churg-Strauss syndrome, two related autoimmune disorders.

Important aspects of granulomas are:

• Whether they are caseating or not. Caseation (literally: turning to cheese) is a form of necrosis at the centre of a granuloma and is a feature of the granulomas of tuberculosis.
• More to be added

Chronic granulomatous disease

In the rare condition chronic granulomatous disease, neutrophil granulocyte function is impaired and granulomas form in various organs in response to infection, as the infection is not being contained through normal means.